Reaction Details | |||
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Target | Receptor tyrosine-protein kinase erbB-2 | ||
Ligand | BDBM50296347 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_581980 (CHEMBL1058960) | ||
IC50 | >10000±n/a nM | ||
Citation | Li, R; Pourpak, A; Morris, SW Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J Med Chem52:4981-5004 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Receptor tyrosine-protein kinase erbB-2 | |||
Name: | Receptor tyrosine-protein kinase erbB-2 | ||
Synonyms: | 2.7.10.1 | C-erbB-2 | CD_antigen=CD340 | ERBB2 | ERBB2_HUMAN | ErbB-2/ErbB-3 heterodimer | FASN/HER2 | HER-2 Substrate | HER2 | MLN 19 | MLN19 | Metastatic lymph node gene 19 protein | NEU | NGL | Proto-oncogene Neu | Proto-oncogene c-ErbB-2 | Tyrosine kinase-type cell surface receptor HER2 | p185erbB2 | ||
Type: | n/a | ||
Mol. Mass.: | 137894.47 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P04626 | ||
Residue: | 1255 | ||
Sequence: |
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BDBM50296347 | |||
n/a | |||
Name | BDBM50296347 | ||
Synonyms: | 5-(3-(benzyloxy)phenyl)-7-(3-(pyrrolidin-1-yl)cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine | CHEMBL558708 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H29N5O | ||
Mol. Mass. | 439.5521 | ||
SMILES | Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@H]1C[C@@H](C1)N1CCCC1 |r,wU:26.32,wD:24.27,(-6.06,2.61,;-6.05,1.07,;-7.38,.3,;-7.39,-1.25,;-6.05,-2.02,;-4.72,-1.25,;-3.24,-1.73,;-2.33,-.47,;-3.24,.78,;-2.77,2.25,;-3.79,3.38,;-3.32,4.85,;-1.81,5.17,;-.78,4.03,;.73,4.35,;1.76,3.2,;3.27,3.52,;4.29,2.37,;5.8,2.69,;6.28,4.16,;5.24,5.31,;3.74,4.98,;-1.25,2.56,;-4.72,.3,;-2.78,-3.19,;-3.47,-4.56,;-2.1,-5.27,;-1.4,-3.9,;-1.64,-6.73,;-2.54,-7.98,;-1.64,-9.23,;-.18,-8.76,;-.17,-7.22,)| | ||
Structure |