Reaction Details | |||
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Target | Neuronal acetylcholine receptor subunit alpha-4 | ||
Ligand | BDBM50296746 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_582486 (CHEMBL1058163) | ||
IC50 | 6980±n/a nM | ||
Citation | O'Donnell, CJ; Peng, L; O'Neill, BT; Arnold, EP; Mather, RJ; Sands, SB; Shrikhande, A; Lebel, LA; Spracklin, DK; Nedza, FM Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists. Bioorg Med Chem Lett19:4747-51 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neuronal acetylcholine receptor subunit alpha-4 | |||
Name: | Neuronal acetylcholine receptor subunit alpha-4 | ||
Synonyms: | ACHA4_RAT | Acra4 | Cholinergic, Nicotinic Alpha4Beta2 | Cholinergic, Nicotinic Alpha4Beta4 | Chrna4 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha4beta2 nAChR) | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Neuronal acetylcholine receptor subunit alpha-4 | ||
Type: | Enzyme | ||
Mol. Mass.: | 70196.44 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | P09483 | ||
Residue: | 630 | ||
Sequence: |
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BDBM50296746 | |||
n/a | |||
Name | BDBM50296746 | ||
Synonyms: | 4-chloro-3-fluorophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate | CHEMBL555703 | ||
Type | Small organic molecule | ||
Emp. Form. | C14H16ClFN2O2 | ||
Mol. Mass. | 298.74 | ||
SMILES | Fc1cc(OC(=O)N2CCN3CCC2CC3)ccc1Cl |TLB:5:7:12.11:14.15,(25.98,-13.32,;24.59,-12.82,;23.41,-13.81,;21.96,-13.28,;20.77,-14.27,;19.32,-13.75,;19.05,-12.22,;18.14,-14.74,;18.5,-16.22,;17.5,-15.49,;16.12,-15.57,;16.04,-13.86,;16.66,-12.7,;16.73,-14.12,;15.43,-14.83,;15.12,-16.27,;21.68,-11.76,;22.86,-10.77,;24.32,-11.29,;25.45,-10.34,)| | ||
Structure |