Reaction Details |
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Target | Aurora kinase C |
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Ligand | BDBM2579 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_587172 (CHEMBL1060236) |
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Kd | 23±n/a nM |
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Citation | Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol26:127-32 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase C |
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Name: | Aurora kinase C |
Synonyms: | AIE2 | AIK3 | AIRK3 | ARK3 | AURKC | AURKC_HUMAN | Aurora Kinase C (Aurora-C) | Aurora kinase C | Aurora kinase C (AURKC) | Aurora-C | Aurora-C/INCENP | Aurora/Ipl1-related kinase 3 | Aurora/Ipl1/Eg2 protein 2 | STK13 | Serine/threonine-protein kinase 13 | Serine/threonine-protein kinase Aurora-C |
Type: | Enzyme |
Mol. Mass.: | 35602.43 |
Organism: | Homo sapiens (Human) |
Description: | Amino acid residues 1-309 were expressed as His-tagged fusion protein using baculovirus expression system. |
Residue: | 309 |
Sequence: | MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLA
RLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLIL
EYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEV
KIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFE
SASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRV
LPPCAQMAS
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BDBM2579 |
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n/a |
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Name | BDBM2579 |
Synonyms: | (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one | CHEMBL388978 | Staurosporin, 4 | Staurosporine | Staurosporine, 8 | US20240002365, Compound staurosporine | US9206188, Staurosporine | US9226923, Staurosporine |
Type | Small organic molecule |
Emp. Form. | C28H26N4O3 |
Mol. Mass. | 466.531 |
SMILES | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| |
Structure |
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