| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform alpha-like |
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| Ligand | BDBM25045 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_586447 (CHEMBL1063703) |
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| Kd | >10000±n/a nM |
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| Citation |  Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol26:127-32 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform alpha-like |
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| Name: | Casein kinase I isoform alpha-like |
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| Synonyms: | CSNK1A1L | Casein kinase I isoform alpha-like | KC1AL_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 39105.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_586447 |
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| Residue: | 337 |
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| Sequence: | MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEDVAVKLESQKVKHPQLLYE
SKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFLHRDIKPDNFLMGTGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKH
LIGTVRYASINAHLGIEQSRRDDMESLGYVFMYFNRTSLPWQGLRAMTKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTQTGKQTEKNKNNVKDN
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| BDBM25045 |
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| n/a |
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| Name | BDBM25045 |
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| Synonyms: | 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol | 3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyrimidin-2-yl)phenol | 3-(4-morpholinopyrido[2,3]furo[2,4-b]pyrimidin-2-yl)phenol | 3-[4-(4-morpholinyl)-2-pyrido[2,3]furo[2,4-b]pyrimidinyl]phenol | 3-[6-(morpholin-4-yl)-8-oxa-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(9),2,4,6,10,12-hexaen-4-yl]phenol | CHEMBL538346 | PI-103 | US9637488, PI-103 | cid_9884685 | mTOR Inhibitor, PI103 | pyridofuropyrimidine derivative, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16N4O3 |
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| Mol. Mass. | 348.3553 |
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| SMILES | Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1 |
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| Structure | 
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