| Reaction Details |
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 | Report a problem with these data |
| Target | SRC |
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| Ligand | BDBM26474 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_586964 |
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| Kd | 1600±n/a nM |
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| Citation |  Karaman MW; Herrgard S; Treiber DK; Gallant P; Atteridge CE; Campbell BT; Chan KW; Ciceri P; Davis MI; Edeen PT; Faraoni R; Floyd M; Hunt JP; Lockhart DJ; Milanov ZV; Morrison MJ; Pallares G; Patel HK; Pritchard S; Wodicka LM; Zarrinkar PP A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 26:127-32 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| SRC |
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| Name: | SRC |
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| Synonyms: | FGR | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | Tyrosine-protein kinase Fgr | Tyrosine-protein kinase Fgr |
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| Type: | protein |
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| Mol. Mass.: | 59469.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P09769 |
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| Residue: | 529 |
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| Sequence: | MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
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| BDBM26474 |
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| n/a |
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| Name | BDBM26474 |
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| Synonyms: | 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide | GW-786034 | JMC514632 Compound 13 | PAZOPANIB | Pazopanib | cid_10113978 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23N7O2S |
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| Mol. Mass. | 437.518 |
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| SMILES | CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1 |
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| Structure | 
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