Ki Summary

Reaction Details

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Target

Cyclin-dependent kinase 16

Ligand

BDBM4851

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_587091 (CHEMBL1051303)

>10000±n/a nM

Citation

Karaman, MW; Herrgard, S; Treiber, DK; Gallant, P; Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Hunt, JP; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Wodicka, LM; Zarrinkar, PP A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol26:127-32 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cyclin-dependent kinase 16

Name:

Cyclin-dependent kinase 16

Synonyms:

CDK16 | CDK16_HUMAN | PCTAIRE1 | PCTK1 | Serine/threonine-protein kinase PCTAIRE-1

Type:

Protein

Mol. Mass.:

55721.58

Organism:

Homo sapiens (Human)

Description:

Q00536

Residue:

496

Sequence:

MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR
GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL
PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY
KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF
EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL
KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP
LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA
DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS
MPDSGRPAFRVVDTEF

BDBM4851

n/a

Name

BDBM4851

Synonyms:

(4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine | (A) PTK787 | CGP 79787 | CHEMBL101253 | CHEMBL75232 | N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine | N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine | PTK-787 | PTK787 | ZK222584 | cid_151194

Type

Small organic molecule

Emp. Form.

C20H15ClN4

Mol. Mass.

346.813

SMILES

Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1

Structure