Ki Summary

Reaction Details

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Target

Cannabinoid receptor 2

Ligand

BDBM50298938

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_588142 (CHEMBL1049259)

>3940±n/a nM

Citation

Silvestri, R; Ligresti, A; La Regina, G; Piscitelli, F; Gatti, V; Brizzi, A; Pasquini, S; Lavecchia, A; Allarà, M; Fantini, N; Carai, MA; Novellino, E; Colombo, G; Di Marzo, V; Corelli, F Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity profile. Bioorg Med Chem17:5549-64 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Cannabinoid receptor 2

Name:

Cannabinoid receptor 2

Synonyms:

CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

39690.94

Organism:

Homo sapiens (Human)

Description:

P34972

Residue:

360

Sequence:

MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

BDBM50298938

n/a

Name

BDBM50298938

Synonyms:

CHEMBL574045 | N-[2-(4-Chlorophenyl)ethyl]1-(3,4-dichlorophenyl)-5-(2,5-dimethyl-1H-pyrrol-1-yl)-4-methyl-1H-pyrazole-3-carboxamide

Type

Small organic molecule

Emp. Form.

C25H23Cl3N4O

Mol. Mass.

501.835

SMILES

Cc1ccc(C)n1-c1c(C)c(nn1-c1ccc(Cl)c(Cl)c1)C(=O)NCCc1ccc(Cl)cc1 |(1.82,-24.7,;2.72,-23.45,;4.25,-23.43,;4.73,-21.97,;3.47,-21.07,;3.46,-19.53,;2.23,-21.99,;.76,-21.52,;.28,-20.06,;1.17,-18.81,;-1.27,-20.07,;-1.73,-21.54,;-.48,-22.43,;-.46,-23.98,;-1.79,-24.75,;-1.78,-26.29,;-.44,-27.06,;-.43,-28.59,;.89,-26.27,;2.23,-27.04,;.88,-24.73,;-2.18,-18.83,;-1.56,-17.42,;-3.71,-19,;-4.62,-17.76,;-6.15,-17.94,;-7.07,-16.7,;-8.6,-16.87,;-9.52,-15.63,;-8.9,-14.22,;-9.81,-12.98,;-7.37,-14.05,;-6.45,-15.29,)|

Structure