Ki Summary

Reaction Details

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Target

5-hydroxytryptamine receptor 3A

Ligand

BDBM50060685

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_592422 (CHEMBL1037808)

64.57±n/a nM

Citation

Butini, S; Budriesi, R; Hamon, M; Morelli, E; Gemma, S; Brindisi, M; Borrelli, G; Novellino, E; Fiorini, I; Ioan, P; Chiarini, A; Cagnotto, A; Mennini, T; Fracasso, C; Caccia, S; Campiani, G Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization. J Med Chem52:6946-50 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

5-hydroxytryptamine receptor 3A

Name:

5-hydroxytryptamine receptor 3A

Synonyms:

5-HT3 | 5-hydroxytryptamine receptor 3A | 5HT3A_CAVPO | 5HT3R | HTR3 | HTR3A | Serotonin 3a (5-HT3a) receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

55657.07

Organism:

GUINEA PIG

Description:

5-HT3 HTR3A GUINEA PIG::O70212

Residue:

490

Sequence:

MVLWLQLALLALLLPTSLAQGEVRGKGTAQAHNSTRPALQRLSDHLLADYRKSVRPVRDW
RKPTTVSIDAIVYAILSVDEKNQVLTTYIWYRQFWTDEFLQWNPEDFDNITKLSIPTDSI
WVPDILINEFVDVGKSPNIPYVYVRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTF
TSWLHTIQDINISLWRLPEKVKSDKSVFMNQGEWELLGVLTEFLEFSDRESRGSFAEMKF
YVVIRRRPLFYAVTLLLPSIFLMIVDIVGFYLPPDSGERVSFKITLLLGYSVFLIIVSDT
LPATAIGTPLISVYFVVCMALLVISLAETILIVRLVHKQDLQQPVPLWLRHLVLERIAGL
LCLGEQLTSHRGPATLQATKTDDFSGSTLLPAMGNHCGPLGGPQDLEKTSRGRGSPPPPP
REASLAMCGLLQELASIRHFLEKREETREVARDWLRVGSVLDKLLFRVYLLAVLAYSITL
VTLWSVWHYA

BDBM50060685

n/a

Name

BDBM50060685

Synonyms:

9-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxaline | 9-fluoro-4-(4-methylpiperazin-1-yl)pyrrolo[1,2-a]quinoxaline | CHEMBL124886

Type

Small organic molecule

Emp. Form.

C16H17FN4

Mol. Mass.

284.3314

SMILES

CN1CCN(CC1)c1nc2cccc(F)c2n2cccc12

Structure