Reaction Details |
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Target | Indoleamine 2,3-dioxygenase 1 |
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Ligand | BDBM50300307 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_590886 (CHEMBL1042996) |
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IC50 | >20000±n/a nM |
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Citation | Yue, EW; Douty, B; Wayland, B; Bower, M; Liu, X; Leffet, L; Wang, Q; Bowman, KJ; Hansbury, MJ; Liu, C; Wei, M; Li, Y; Wynn, R; Burn, TC; Koblish, HK; Fridman, JS; Metcalf, B; Scherle, PA; Combs, AP Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J Med Chem52:7364-7 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Indoleamine 2,3-dioxygenase 1 |
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Name: | Indoleamine 2,3-dioxygenase 1 |
Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
Type: | Enzyme |
Mol. Mass.: | 45330.80 |
Organism: | Homo sapiens (Human) |
Description: | P14902 |
Residue: | 403 |
Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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BDBM50300307 |
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n/a |
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Name | BDBM50300307 |
Synonyms: | 4-Aamino-N-(3-chlorophenyl)-N'-methoxy-1,2,5-oxadiazole-3-carboximidamide | CHEMBL565924 |
Type | Small organic molecule |
Emp. Form. | C10H10ClN5O2 |
Mol. Mass. | 267.672 |
SMILES | CON=C(Nc1cccc(Cl)c1)c1nonc1N |w:2.1| |
Structure |
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