| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM50300305 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_590896 (CHEMBL1043006) |
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| IC50 | 1000±n/a nM |
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| Citation |  Yue, EW; Douty, B; Wayland, B; Bower, M; Liu, X; Leffet, L; Wang, Q; Bowman, KJ; Hansbury, MJ; Liu, C; Wei, M; Li, Y; Wynn, R; Burn, TC; Koblish, HK; Fridman, JS; Metcalf, B; Scherle, PA; Combs, AP Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J Med Chem52:7364-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_MOUSE | IDO-1 | Ido | Ido1 | Indo | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45639.39 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1452149 |
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| Residue: | 407 |
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| Sequence: | MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLR
EEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSE
KLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASP
AIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSG
WKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMR
EYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMK
PSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP
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| BDBM50300305 |
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| n/a |
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| Name | BDBM50300305 |
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| Synonyms: | 4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide | CHEMBL584991 | US10669273, Compound INCB024360 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H7ClFN5O2 |
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| Mol. Mass. | 271.636 |
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| SMILES | Nc1nonc1C(NO)=Nc1ccc(F)c(Cl)c1 |w:9.10| |
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| Structure | 
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