| Reaction Details |
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 | Report a problem with these data |
| Target | NPC1-like intracellular cholesterol transporter 1 |
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| Ligand | BDBM50300992 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598107 (CHEMBL1038289) |
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| IC50 | 44±n/a nM |
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| Citation |  Simeone, JP; Braun, MP; Leone, JF; Lin, P; DeVita, RJ; Garcia-Calvo, M; Bull, HG; Lisnock, J; Dean, DC Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand. Bioorg Med Chem Lett19:5033-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NPC1-like intracellular cholesterol transporter 1 |
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| Name: | NPC1-like intracellular cholesterol transporter 1 |
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| Synonyms: | NPCL1_MOUSE | Niemann-Pick C1-like protein 1 | Npc1l1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 147132.16 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_598107 |
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| Residue: | 1333 |
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| Sequence: | MAAAWQGWLLWALLLNSAQGELYTPTHKAGFCTFYEECGKNPELSGGLTSLSNISCLSNT
PARHVTGDHLALLQRVCPRLYNGPNDTYACCSTKQLVSLDSSLSITKALLTRCPACSENF
VSIHCHNTCSPDQSLFINVTRVVQRDPGQLPAVVAYEAFYQRSFAEKAYESCSRVRIPAA
ASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALADGMKPLDGKI
TPCNESQGEDSAACSCQDCAASCPVIPPPPALRPSFYMGRMPGWLALIIIFTAVFVLLSV
VLVYLRVASNRNKNKTAGSQEAPNLPRKRRFSPHTVLGRFFESWGTRVASWPLTVLALSF
IVVIALSVGLTFIELTTDPVELWSAPKSQARKEKAFHDEHFGPFFRTNQIFVTAKNRSSY
KYDSLLLGPKNFSGILSLDLLQELLELQERLRHLQVWSHEAQRNISLQDICYAPLNPHNT
SLTDCCVNSLLQYFQNNHTLLLLTANQTLNGQTSLVDWKDHFLYCANAPLTYKDGTALAL
SCIADYGAPVFPFLAVGGYQGTDYSEAEALIITFSINNYPADDPRMAHAKLWEEAFLKEM
QSFQRSTADKFQIAFSAERSLEDEINRTTIQDLPVFAISYLIVFLYISLALGSYSRWSRV
AVDSKATLGLGGVAVVLGAVVAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLE
YQRLPRMPGEQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLAI
IFDFLLQMTAFVALLSLDSKRQEASRPDVVCCFSSRNLPPPKQKEGLLLCFFRKIYTPFL
LHRFIRPVVLLLFLVLFGANLYLMCNISVGLDQDLALPKDSYLIDYFLFLNRYLEVGPPV
YFDTTSGYNFSTEAGMNAICSSAGCESFSLTQKIQYASEFPNQSYVAIAASSWVDDFIDW
LTPSSSCCRIYTRGPHKDEFCPSTDTSFNCLKNCMNRTLGPVRPTTEQFHKYLPWFLNDT
PNIRCPKGGLAAYRTSVNLSSDGQIIASQFMAYHKPLRNSQDFTEALRASRLLAANITAE
LRKVPGTDPNFEVFPYTISNVFYQQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDIRSGI
LNLLSIIMILVDTIGLMAVWGISYNAVSLINLVTAVGMSVEFVSHITRSFAVSTKPTRLE
RAKDATIFMGSAVFAGVAMTNFPGILILGFAQAQLIQIFFFRLNLLITLLGLLHGLVFLP
VVLSYLGPDVNQALVLEEKLATEAAMVSEPSCPQYPFPADANTSDYVNYGFNPEFIPEIN
AASSSLPKSDQKF
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| BDBM50300992 |
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| n/a |
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| Name | BDBM50300992 |
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| Synonyms: | (2S,3S,4S,5R,6S)-6-(4-{(2S,3R)-3-[(S)-3-(4-Fluoro-phenyl)-3-hydroxy-propyl]-1-[4-(3-methane[35S]sulfonylamino-prop-1-ynyl)-phenyl]-4-oxo-azetidin-2-yl}-phenoxy)-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid | CHEMBL578400 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H35FN2O11S |
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| Mol. Mass. | 698.712 |
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| SMILES | CS(=O)(=O)NCC#Cc1ccc(cc1)N1[C@@H]([C@@H](CC[C@H](O)c2ccc(F)cc2)C1=O)c1ccc(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(O)=O)cc1 |r| |
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| Structure | 
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