Reaction Details |
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Target | Sodium/glucose cotransporter 2 |
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Ligand | BDBM50302616 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_594780 (CHEMBL1040741) |
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IC50 | 36±n/a nM |
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Citation | Goodwin, NC; Mabon, R; Harrison, BA; Shadoan, MK; Almstead, ZY; Xie, Y; Healy, J; Buhring, LM; DaCosta, CM; Bardenhagen, J; Mseeh, F; Liu, Q; Nouraldeen, A; Wilson, AG; Kimball, SD; Powell, DR; Rawlins, DB Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. J Med Chem52:6201-4 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/glucose cotransporter 2 |
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Name: | Sodium/glucose cotransporter 2 |
Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
Type: | Protein |
Mol. Mass.: | 72902.00 |
Organism: | Homo sapiens (Human) |
Description: | P31639 |
Residue: | 672 |
Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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BDBM50302616 |
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n/a |
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Name | BDBM50302616 |
Synonyms: | (2S,3R,4R,5S)-2-(4-Chloro-3-(4-(2-hydroxyethoxy)benzyl)phenyl)-6-methoxytetrahydro-2Hpyran-3,4,5-triol | CHEMBL567743 |
Type | Small organic molecule |
Emp. Form. | C21H25ClO7 |
Mol. Mass. | 424.872 |
SMILES | COC1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc(Cl)c(Cc2ccc(OCCO)cc2)c1 |r| |
Structure |
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