Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPteridine reductase 1
LigandBDBM6644
Substrate/Competitorn/a
Meas. Tech.ChEMBL_596055
Ki 3400±n/a nM
Citation Tulloch LBMartini VPIulek JHuggan JKLee JHGibson CLSmith TKSuckling CJHunter WN Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. J Med Chem 53:221-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Pteridine reductase 1
Name:Pteridine reductase 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:30459.34
Organism:Leishmania major
Description:ChEMBL_1470027
Residue:288
Sequence:
MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM6644
n/a
NameBDBM6644
Synonyms:6‐phenylpteridine‐2,4,7‐triamine (5) | 6-phenylpteridine-2,4,7-triamine | Pteridine deriv. 11 | TRIAMTERENE
TypeSmall organic molecule
Emp. Form.C12H11N7
Mol. Mass.253.2626
SMILESNc1nc(N)c2nc(c(N)nc2n1)-c1ccccc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: