Reaction Details |
| Report a problem with these data |
Target | Pteridine reductase 1 |
---|
Ligand | BDBM50303517 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_596055 (CHEMBL1037349) |
---|
Ki | 27000±n/a nM |
---|
Citation | Tulloch, LB; Martini, VP; Iulek, J; Huggan, JK; Lee, JH; Gibson, CL; Smith, TK; Suckling, CJ; Hunter, WN Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. J Med Chem53:221-9 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Pteridine reductase 1 |
---|
Name: | Pteridine reductase 1 |
Synonyms: | HMTXR | PTR1 | PTR1_LEIMA |
Type: | PROTEIN |
Mol. Mass.: | 30459.34 |
Organism: | Leishmania major |
Description: | ChEMBL_1470027 |
Residue: | 288 |
Sequence: | MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAI
TVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLR
NDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMV
DAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEG
HRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA
|
|
|
BDBM50303517 |
---|
n/a |
---|
Name | BDBM50303517 |
Synonyms: | 2,4-diamino-6-(p-tolylthio)pyrimidin-1-ium | 6-[(4-methylphenyl)sulfanyl]pyrimidine-2,4-diamine | CHEMBL578789 |
Type | Small organic molecule |
Emp. Form. | C11H12N4S |
Mol. Mass. | 232.305 |
SMILES | Cc1ccc(Sc2cc(N)nc(N)n2)cc1 |
Structure |
|