Reaction Details |
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Target | Thymidine phosphorylase |
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Ligand | BDBM50378688 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_607910 (CHEMBL1066238) |
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IC50 | 220±n/a nM |
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Citation | Kocalka, P; Rejman, D; Vanek, V; Rinnová, M; Tomecková, I; Králíková, S; Petrová, M; Páv, O; Pohl, R; Budesínský, M; Liboska, R; Tocík, Z; Panova, N; Votruba, I; Rosenberg, I Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase. Bioorg Med Chem Lett20:862-5 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thymidine phosphorylase |
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Name: | Thymidine phosphorylase |
Synonyms: | Ecgf1 | TP | TYPH_RAT | TdRPase | Tymp |
Type: | PROTEIN |
Mol. Mass.: | 49897.36 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_607910 |
Residue: | 476 |
Sequence: | MAAPGTPPPLAPETAGADSGGGSGEHRQLPELIRLKRNGGHLSEADIRNFVHALMDGRAQ
DTQIGAMLMAIRLQGMDLEETSVLTQALAESGQQLEWPKAWHQQLVDKHSTGGVGDKVSL
VLAPALAACGCKVPMISGRSLGHTGGTLDKLESIPGFSVTQSPEQMLQILEEVGCCIVGQ
SEKLVPADGILYAARDVTATVDSVPLITASILSKKAVEGLSTLVVDVKFGGAAVFPDQEK
ARELAKMLVRVGMGLGLQVAAALTAMDNPLGRNVGHTLEVEEALLCLDGAGPPDLRDLVI
RLGGAILWLSGQAETQDQGAARVAAALDDGSALHRFQLMLSAQGVDPGLARALCSGSPTQ
RRQLLPHARKQEELLSPADGIVECVRALPLACVLHELGAGRSRAGQPIRPGVGAELLVDV
GQWLSRGTPWLRVHLDGPALSSQQRRTLLGALVLSDRAPFKAPSPFAELVLPPTTP
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BDBM50378688 |
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n/a |
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Name | BDBM50378688 |
Synonyms: | CHEMBL599562 |
Type | Small organic molecule |
Emp. Form. | C10H14N3O7P |
Mol. Mass. | 319.2078 |
SMILES | Cc1cn([C@@H]2CN(C[C@H]2O)C(=O)P(O)(O)=O)c(=O)[nH]c1=O |r| |
Structure |
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