| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM50378691 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_607910 (CHEMBL1066238) |
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| IC50 | 15±n/a nM |
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| Citation |  Kocalka, P; Rejman, D; Vanek, V; Rinnová, M; Tomecková, I; Králíková, S; Petrová, M; Páv, O; Pohl, R; Budesínský, M; Liboska, R; Tocík, Z; Panova, N; Votruba, I; Rosenberg, I Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase. Bioorg Med Chem Lett20:862-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | Ecgf1 | TP | TYPH_RAT | TdRPase | Tymp |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49897.36 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_607910 |
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| Residue: | 476 |
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| Sequence: | MAAPGTPPPLAPETAGADSGGGSGEHRQLPELIRLKRNGGHLSEADIRNFVHALMDGRAQ
DTQIGAMLMAIRLQGMDLEETSVLTQALAESGQQLEWPKAWHQQLVDKHSTGGVGDKVSL
VLAPALAACGCKVPMISGRSLGHTGGTLDKLESIPGFSVTQSPEQMLQILEEVGCCIVGQ
SEKLVPADGILYAARDVTATVDSVPLITASILSKKAVEGLSTLVVDVKFGGAAVFPDQEK
ARELAKMLVRVGMGLGLQVAAALTAMDNPLGRNVGHTLEVEEALLCLDGAGPPDLRDLVI
RLGGAILWLSGQAETQDQGAARVAAALDDGSALHRFQLMLSAQGVDPGLARALCSGSPTQ
RRQLLPHARKQEELLSPADGIVECVRALPLACVLHELGAGRSRAGQPIRPGVGAELLVDV
GQWLSRGTPWLRVHLDGPALSSQQRRTLLGALVLSDRAPFKAPSPFAELVLPPTTP
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| BDBM50378691 |
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| n/a |
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| Name | BDBM50378691 |
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| Synonyms: | CHEMBL609919 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14N3O6PS |
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| Mol. Mass. | 335.273 |
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| SMILES | Cc1cn([C@@H]2CN(C[C@@H]2O)C(=S)P(O)(O)=O)c(=O)[nH]c1=O |r| |
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| Structure | 
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