| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl pyrophosphate synthase |
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| Ligand | BDBM50318032 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_631184 (CHEMBL1110033) |
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| IC50 | >1000000±n/a nM |
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| Citation |  McKenna, CE; Kashemirov, BA; Blazewska, KM; Mallard-Favier, I; Stewart, CA; Rojas, J; Lundy, MW; Ebetino, FH; Baron, RA; Dunford, JE; Kirsten, ML; Seabra, MC; Bala, JL; Marma, MS; Rogers, MJ; Coxon, FP Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid. J Med Chem53:3454-64 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Geranylgeranyl pyrophosphate synthase |
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| Name: | Geranylgeranyl pyrophosphate synthase |
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| Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
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| Type: | Homooctamer; transferase |
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| Mol. Mass.: | 34867.94 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
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| Residue: | 300 |
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| Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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| BDBM50318032 |
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| n/a |
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| Name | BDBM50318032 |
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| Synonyms: | (+)-2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid | (+/-)-2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid | (-)-2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid | (2-HYDROXY-3-IMIDAZO[1,2-A]PYRIDIN-3-YL-2-PHOSPHONOPROPIONIC ACID (ENANTIONMERS) | CHEMBL1099309 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H11N2O6P |
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| Mol. Mass. | 286.1779 |
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| SMILES | OC(=O)C(O)(Cc1cnc2ccccn12)P(O)(O)=O |
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| Structure | 
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