| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50318269 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_629506 (CHEMBL1120795) |
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| Ki | >10000±n/a nM |
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| Citation |  Taliani, S; La Motta, C; Mugnaini, L; Simorini, F; Salerno, S; Marini, AM; Da Settimo, F; Cosconati, S; Cosimelli, B; Greco, G; Limongelli, V; Marinelli, L; Novellino, E; Ciampi, O; Daniele, S; Trincavelli, ML; Martini, C Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation. J Med Chem53:3954-63 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36520.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30542 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
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| BDBM50318269 |
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| n/a |
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| Name | BDBM50318269 |
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| Synonyms: | 1-(2-benzyl-6-phenyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)-3-(4-methoxyphenyl)urea | CHEMBL1096078 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22N6O2 |
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| Mol. Mass. | 450.4919 |
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| SMILES | COc1ccc(NC(=O)Nc2nc(nc3nn(Cc4ccccc4)cc23)-c2ccccc2)cc1 |
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| Structure | 
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