| Reaction Details |
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 | Report a problem with these data |
| Target | Dynamin-1 |
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| Ligand | BDBM50318676 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_633480 (CHEMBL1119292) |
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| IC50 | 690000±n/a nM |
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| Citation |  Odell, LR; Howan, D; Gordon, CP; Robertson, MJ; Chau, N; Mariana, A; Whiting, AE; Abagyan, R; Daniel, JA; Gorgani, NN; Robinson, PJ; McCluskey, A The pthaladyns: GTP competitive inhibitors of dynamin I and II GTPase derived from virtual screening. J Med Chem53:5267-80 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dynamin-1 |
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| Name: | Dynamin-1 |
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| Synonyms: | DYN1_RAT | Dnm | Dnm1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97296.32 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_633480 |
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| Residue: | 864 |
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| Sequence: | MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLVLQLVNSTTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPI
NLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSD
LANSDALKIAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKL
QSQLLSIEKEVDEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGA
RINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDLAFEATVKKQVQKL
KEPSIKCVDMVVSELTSTIRKCSEKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLID
IELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKE
YWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY
RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVE
TIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAE
QAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT
PQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAP
PGVPSRSGQASPSRPESPRPPFDL
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| BDBM50318676 |
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| n/a |
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| Name | BDBM50318676 |
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| Synonyms: | 4-Chloro-2-{[2-(4-hydroxymethylphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carbonyl]amino}benzoic Acid | CHEMBL1084521 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H15ClN2O6 |
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| Mol. Mass. | 450.828 |
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| SMILES | OCc1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)Nc1cc(Cl)ccc1C(O)=O |
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| Structure | 
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