Compile Data Set for Download or QSAR

Found 37 hits with Last Name = 'mariana' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dynamin-2 (Homo sapiens (Human))	BDBM50316543 (CHEMBL1094197 | N,N'-(Propane-1,3-diyl)bis(6,7-dih...) Show SMILES Oc1cc2cc(C(=O)NCCCNC(=O)c3cc4cc(O)c(O)cc4oc3=N)c(=N)oc2cc1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(4-10-6-14(28)16(30)8-18(10)34-20)22(32)26-2-1-3-27-23(33)13-5-11-7-15(29)17(31)9-19(11)35-21(13)25/h4-9,24-25,28-31H,1-3H2,(H,26,32)(H,27,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316542 (CHEMBL1098764 | N,N'-(Propane-1,3-diyl)bis(7,8-dih...) Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(8-10-2-4-14(28)16(30)18(10)34-20)22(32)26-6-1-7-27-23(33)13-9-11-3-5-15(29)17(31)19(11)35-21(13)25/h2-5,8-9,24-25,28-31H,1,6-7H2,(H,26,32)(H,27,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316539 (CHEMBL1094850 | N,N'-(Ethane-1,2-diyl)bis(7,8-dihy...) Show SMILES Oc1ccc2cc(C(=O)NCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O Show InChI InChI=1S/C22H18N4O8/c23-19-11(7-9-1-3-13(27)15(29)17(9)33-19)21(31)25-5-6-26-22(32)12-8-10-2-4-14(28)16(30)18(10)34-20(12)24/h1-4,7-8,23-24,27-30H,5-6H2,(H,25,31)(H,26,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50423883 (CHEMBL2312430) Show SMILES CCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12 Show InChI InChI=1S/C24H41N3/c1-4-5-6-7-8-9-10-13-17-25-20-22-21-27(19-14-18-26(2)3)24-16-12-11-15-23(22)24/h11-12,15-16,21,25H,4-10,13-14,17-20H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins				J Med Chem 56: 46-59 (2013) Article DOI: 10.1021/jm300844m BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50423885 (CHEMBL2312431) Show SMILES CCCCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12 Show InChI InChI=1S/C26H45N3/c1-4-5-6-7-8-9-10-11-12-15-19-27-22-24-23-29(21-16-20-28(2)3)26-18-14-13-17-25(24)26/h13-14,17-18,23,27H,4-12,15-16,19-22H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins				J Med Chem 56: 46-59 (2013) Article DOI: 10.1021/jm300844m BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50423888 (CHEMBL2312414) Show SMILES CCCCCCCCNC(=O)C(=C\c1cn(CC(O)CN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C25H36N4O2/c1-4-5-6-7-8-11-14-27-25(31)20(16-26)15-21-17-29(19-22(30)18-28(2)3)24-13-10-9-12-23(21)24/h9-10,12-13,15,17,22,30H,4-8,11,14,18-19H2,1-3H3,(H,27,31)/b20-15+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins				J Med Chem 56: 46-59 (2013) Article DOI: 10.1021/jm300844m BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50423886 (CHEMBL2312428) Show SMILES CCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12 Show InChI InChI=1S/C22H37N3/c1-4-5-6-7-8-11-15-23-18-20-19-25(17-12-16-24(2)3)22-14-10-9-13-21(20)22/h9-10,13-14,19,23H,4-8,11-12,15-18H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins				J Med Chem 56: 46-59 (2013) Article DOI: 10.1021/jm300844m BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50423887 (CHEMBL2312415) Show SMILES CCCCCCCCNC(=O)C(=C\c1c(C)n(CC(O)CN2CCCC2)c2ccccc12)\C#N Show InChI InChI=1S/C28H40N4O2/c1-3-4-5-6-7-10-15-30-28(34)23(19-29)18-26-22(2)32(27-14-9-8-13-25(26)27)21-24(33)20-31-16-11-12-17-31/h8-9,13-14,18,24,33H,3-7,10-12,15-17,20-21H2,1-2H3,(H,30,34)/b23-18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins				J Med Chem 56: 46-59 (2013) Article DOI: 10.1021/jm300844m BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50268295 (2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-in...) Show SMILES CCCCCCCCNC(=O)C(=C\c1cn(CCCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C25H36N4O/c1-4-5-6-7-8-11-15-27-25(30)21(19-26)18-22-20-29(17-12-16-28(2)3)24-14-10-9-13-23(22)24/h9-10,13-14,18,20H,4-8,11-12,15-17H2,1-3H3,(H,27,30)/b21-18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins				J Med Chem 56: 46-59 (2013) Article DOI: 10.1021/jm300844m BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50268295 (2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-in...) Show SMILES CCCCCCCCNC(=O)C(=C\c1cn(CCCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C25H36N4O/c1-4-5-6-7-8-11-15-27-25(30)21(19-26)18-22-20-29(17-12-16-28(2)3)24-14-10-9-13-23(22)24/h9-10,13-14,18,20H,4-8,11-12,15-17H2,1-3H3,(H,27,30)/b21-18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins				J Med Chem 52: 3762-73 (2009) Article DOI: 10.1021/jm900036m BindingDB Entry DOI: 10.7270/Q28W3D79
					More data for this Ligand-Target Pair
Dynamin-2 (Rattus norvegicus)	BDBM50423883 (CHEMBL2312430) Show SMILES CCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12 Show InChI InChI=1S/C24H41N3/c1-4-5-6-7-8-9-10-13-17-25-20-22-21-27(19-14-18-26(2)3)24-16-12-11-15-23(22)24/h11-12,15-16,21,25H,4-10,13-14,17-20H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of rat full length His6-tagged dyn2 using phosphotidylserine as substrate after 90 mins by malachite green GTPase assay in presence of GTP				J Med Chem 56: 46-59 (2013) Article DOI: 10.1021/jm300844m BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50388829 (CHEMBL2062753) Show SMILES CN(C)CCCOc1ccc(\C=C2/SC(=S)N(CC=C)C2=O)cc1 Show InChI InChI=1S/C18H22N2O2S2/c1-4-10-20-17(21)16(24-18(20)23)13-14-6-8-15(9-7-14)22-12-5-11-19(2)3/h4,6-9,13H,1,5,10-12H2,2-3H3/b16-13-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of dynamin1-mediated endocytosis in human U2OS cells assessed as inhibition of Texas red-Tf uptake incubated for 30 mins prior to Texas re...				ACS Med Chem Lett 3: 352-356 (2012) Article DOI: 10.1021/ml200284s BindingDB Entry DOI: 10.7270/Q2V40W83
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50423884 (CHEMBL2312432) Show SMILES CCCCCCCCCCCCCCNCc1cn(CCCN(C)C)c2ccccc12 Show InChI InChI=1S/C28H49N3/c1-4-5-6-7-8-9-10-11-12-13-14-17-21-29-24-26-25-31(23-18-22-30(2)3)28-20-16-15-19-27(26)28/h15-16,19-20,25,29H,4-14,17-18,21-24H2,1-3H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dyn2 in human U2OS cells assessed as clathrin-mediated endocytosis of Tfn after 30 mins				J Med Chem 56: 46-59 (2013) Article DOI: 10.1021/jm300844m BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50388828 (CHEMBL2062743) Show SMILES CCN1C(=S)S\C(=C/c2ccc(OCCCN(C)C)cc2)C1=O Show InChI InChI=1S/C17H22N2O2S2/c1-4-19-16(20)15(23-17(19)22)12-13-6-8-14(9-7-13)21-11-5-10-18(2)3/h6-9,12H,4-5,10-11H2,1-3H3/b15-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of dynamin1-mediated endocytosis in human U2OS cells assessed as inhibition of Texas red-Tf uptake incubated for 30 mins prior to Texas re...				ACS Med Chem Lett 3: 352-356 (2012) Article DOI: 10.1021/ml200284s BindingDB Entry DOI: 10.7270/Q2V40W83
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316542 (CHEMBL1098764 | N,N'-(Propane-1,3-diyl)bis(7,8-dih...) Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(8-10-2-4-14(28)16(30)18(10)34-20)22(32)26-6-1-7-27-23(33)13-9-11-3-5-15(29)17(31)19(11)35-21(13)25/h2-5,8-9,24-25,28-31H,1,6-7H2,(H,26,32)(H,27,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50268962 (2-Cyano-N-octyl-3-[1-(3-dimethylaminopropyl)-2-met...) Show SMILES CCCCCCCCNC(=O)C(=C\c1c(C)n(CCCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C26H38N4O/c1-5-6-7-8-9-12-16-28-26(31)22(20-27)19-24-21(2)30(18-13-17-29(3)4)25-15-11-10-14-23(24)25/h10-11,14-15,19H,5-9,12-13,16-18H2,1-4H3,(H,28,31)/b22-19+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins				J Med Chem 52: 3762-73 (2009) Article DOI: 10.1021/jm900036m BindingDB Entry DOI: 10.7270/Q28W3D79
					More data for this Ligand-Target Pair
Dynamin-1 (Rattus norvegicus)	BDBM50318675 (4-Chloro-2-{[2-(3-nitrophenyl)-1,3-dioxo-2,3-dihyd...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C22H12ClN3O7/c23-12-5-7-16(22(30)31)18(9-12)24-19(27)11-4-6-15-17(8-11)21(29)25(20(15)28)13-2-1-3-14(10-13)26(32)33/h1-10H,(H,24,27)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...				J Med Chem 53: 5267-80 (2010) Article DOI: 10.1021/jm100442u BindingDB Entry DOI: 10.7270/Q2PV6MBN
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50268872 (2-Cyano-N-octyl-3-[1-(2-dimethylaminoethyl)-2-meth...) Show SMILES CCCCCCCCNC(=O)C(=C\c1c(C)n(CCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C25H36N4O/c1-5-6-7-8-9-12-15-27-25(30)21(19-26)18-23-20(2)29(17-16-28(3)4)24-14-11-10-13-22(23)24/h10-11,13-14,18H,5-9,12,15-17H2,1-4H3,(H,27,30)/b21-18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins				J Med Chem 52: 3762-73 (2009) Article DOI: 10.1021/jm900036m BindingDB Entry DOI: 10.7270/Q28W3D79
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50268961 (2-Cyano-N-hexyl-3-[1-(3-dimethylaminopropyl)-2-met...) Show SMILES CCCCCCNC(=O)C(=C\c1c(C)n(CCCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C24H34N4O/c1-5-6-7-10-14-26-24(29)20(18-25)17-22-19(2)28(16-11-15-27(3)4)23-13-9-8-12-21(22)23/h8-9,12-13,17H,5-7,10-11,14-16H2,1-4H3,(H,26,29)/b20-17+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins				J Med Chem 52: 3762-73 (2009) Article DOI: 10.1021/jm900036m BindingDB Entry DOI: 10.7270/Q28W3D79
					More data for this Ligand-Target Pair
Dynamin-2 (Rattus norvegicus)	BDBM50268295 (2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-in...) Show SMILES CCCCCCCCNC(=O)C(=C\c1cn(CCCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C25H36N4O/c1-4-5-6-7-8-11-15-27-25(30)21(19-26)18-22-20-29(17-12-16-28(2)3)24-14-10-9-13-23(22)24/h9-10,13-14,18,20H,4-8,11-12,15-17H2,1-3H3,(H,27,30)/b21-18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of rat full length His6-tagged dyn2 using phosphotidylserine as substrate after 90 mins by malachite green GTPase assay in presence of GTP				J Med Chem 56: 46-59 (2013) Article DOI: 10.1021/jm300844m BindingDB Entry DOI: 10.7270/Q2DJ5GZ3
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316541 (CHEMBL1096801 | N,N'-(Propane-1,3-diyl)bis(7-hydro...) Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)cc4oc3=N)c(=N)oc2c1 Show InChI InChI=1S/C23H20N4O6/c24-20-16(8-12-2-4-14(28)10-18(12)32-20)22(30)26-6-1-7-27-23(31)17-9-13-3-5-15(29)11-19(13)33-21(17)25/h2-5,8-11,24-25,28-29H,1,6-7H2,(H,26,30)(H,27,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50388827 (CHEMBL2062731) Show SMILES SC1=NC(=O)C(S1)=Cc1cc(Cl)cc(Cl)c1 |w:7.8,t:1| Show InChI InChI=1S/C10H5Cl2NOS2/c11-6-1-5(2-7(12)4-6)3-8-9(14)13-10(15)16-8/h1-4H,(H,13,14,15)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.81E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of dynamin1-mediated endocytosis in human U2OS cells assessed as inhibition of Texas red-Tf uptake incubated for 30 mins prior to Texas re...				ACS Med Chem Lett 3: 352-356 (2012) Article DOI: 10.1021/ml200284s BindingDB Entry DOI: 10.7270/Q2V40W83
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316540 (CHEMBL1098763 | N,N'-(Propane-1,3-diyl)bis(8-hydro...) Show SMILES Oc1cccc2cc(C(=O)NCCCNC(=O)c3cc4cccc(O)c4oc3=N)c(=N)oc12 Show InChI InChI=1S/C23H20N4O6/c24-20-14(10-12-4-1-6-16(28)18(12)32-20)22(30)26-8-3-9-27-23(31)15-11-13-5-2-7-17(29)19(13)33-21(15)25/h1-2,4-7,10-11,24-25,28-29H,3,8-9H2,(H,26,30)(H,27,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.48E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50318676 (4-Chloro-2-{[2-(4-hydroxymethylphenyl)-1,3-dioxo-2...) Show SMILES OCc1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)Nc1cc(Cl)ccc1C(O)=O Show InChI InChI=1S/C23H15ClN2O6/c24-14-4-8-17(23(31)32)19(10-14)25-20(28)13-3-7-16-18(9-13)22(30)26(21(16)29)15-5-1-12(11-27)2-6-15/h1-10,27H,11H2,(H,25,28)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method				J Med Chem 53: 5267-80 (2010) Article DOI: 10.1021/jm100442u BindingDB Entry DOI: 10.7270/Q2PV6MBN
					More data for this Ligand-Target Pair
Dynamin-1 (Rattus norvegicus)	BDBM50316543 (CHEMBL1094197 | N,N'-(Propane-1,3-diyl)bis(6,7-dih...) Show SMILES Oc1cc2cc(C(=O)NCCCNC(=O)c3cc4cc(O)c(O)cc4oc3=N)c(=N)oc2cc1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(4-10-6-14(28)16(30)8-18(10)34-20)22(32)26-2-1-3-27-23(33)13-5-11-7-15(29)17(31)9-19(11)35-21(13)25/h4-9,24-25,28-31H,1-3H2,(H,26,32)(H,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316540 (CHEMBL1098763 | N,N'-(Propane-1,3-diyl)bis(8-hydro...) Show SMILES Oc1cccc2cc(C(=O)NCCCNC(=O)c3cc4cccc(O)c4oc3=N)c(=N)oc12 Show InChI InChI=1S/C23H20N4O6/c24-20-14(10-12-4-1-6-16(28)18(12)32-20)22(30)26-8-3-9-27-23(31)15-11-13-5-2-7-17(29)19(13)33-21(15)25/h1-2,4-7,10-11,24-25,28-29H,3,8-9H2,(H,26,30)(H,27,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50268963 (2-Cyano-N-decyl-3-[1-(2-dimethylaminoethyl)-2-meth...) Show SMILES CCCCCCCCCCNC(=O)C(=C\c1c(C)n(CCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C27H40N4O/c1-5-6-7-8-9-10-11-14-17-29-27(32)23(21-28)20-25-22(2)31(19-18-30(3)4)26-16-13-12-15-24(25)26/h12-13,15-16,20H,5-11,14,17-19H2,1-4H3,(H,29,32)/b23-20+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins				J Med Chem 52: 3762-73 (2009) Article DOI: 10.1021/jm900036m BindingDB Entry DOI: 10.7270/Q28W3D79
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50318675 (4-Chloro-2-{[2-(3-nitrophenyl)-1,3-dioxo-2,3-dihyd...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C22H12ClN3O7/c23-12-5-7-16(22(30)31)18(9-12)24-19(27)11-4-6-15-17(8-11)21(29)25(20(15)28)13-2-1-3-14(10-13)26(32)33/h1-10H,(H,24,27)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method				J Med Chem 53: 5267-80 (2010) Article DOI: 10.1021/jm100442u BindingDB Entry DOI: 10.7270/Q2PV6MBN
					More data for this Ligand-Target Pair
Dynamin-1 (Rattus norvegicus)	BDBM50316541 (CHEMBL1096801 | N,N'-(Propane-1,3-diyl)bis(7-hydro...) Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)cc4oc3=N)c(=N)oc2c1 Show InChI InChI=1S/C23H20N4O6/c24-20-16(8-12-2-4-14(28)10-18(12)32-20)22(30)26-6-1-7-27-23(31)17-9-13-3-5-15(29)11-19(13)33-21(17)25/h2-5,8-11,24-25,28-29H,1,6-7H2,(H,26,30)(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.61E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50318674 (4-Chloro-2-{[2-(2-hydroxyphenyl)-1,3-dioxo-2,3-dih...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccccc1O Show InChI InChI=1S/C22H13ClN2O6/c23-12-6-8-14(22(30)31)16(10-12)24-19(27)11-5-7-13-15(9-11)21(29)25(20(13)28)17-3-1-2-4-18(17)26/h1-10,26H,(H,24,27)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method				J Med Chem 53: 5267-80 (2010) Article DOI: 10.1021/jm100442u BindingDB Entry DOI: 10.7270/Q2PV6MBN
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316543 (CHEMBL1094197 | N,N'-(Propane-1,3-diyl)bis(6,7-dih...) Show SMILES Oc1cc2cc(C(=O)NCCCNC(=O)c3cc4cc(O)c(O)cc4oc3=N)c(=N)oc2cc1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(4-10-6-14(28)16(30)8-18(10)34-20)22(32)26-2-1-3-27-23(33)13-5-11-7-15(29)17(31)9-19(11)35-21(13)25/h4-9,24-25,28-31H,1-3H2,(H,26,32)(H,27,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Rattus norvegicus)	BDBM50316542 (CHEMBL1098764 | N,N'-(Propane-1,3-diyl)bis(7,8-dih...) Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(8-10-2-4-14(28)16(30)18(10)34-20)22(32)26-6-1-7-27-23(33)13-9-11-3-5-15(29)17(31)19(11)35-21(13)25/h2-5,8-9,24-25,28-31H,1,6-7H2,(H,26,32)(H,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.95E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50388830 (CHEMBL2062756) Show SMILES OC(=O)CN1C(=S)S\C(=C/c2csc3ccc(Cl)cc23)C1=O Show InChI InChI=1S/C14H8ClNO3S3/c15-8-1-2-10-9(4-8)7(6-21-10)3-11-13(19)16(5-12(17)18)14(20)22-11/h1-4,6H,5H2,(H,17,18)/b11-3-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of dynamin1-mediated endocytosis in human U2OS cells assessed as inhibition of Texas red-Tf uptake incubated for 30 mins prior to Texas re...				ACS Med Chem Lett 3: 352-356 (2012) Article DOI: 10.1021/ml200284s BindingDB Entry DOI: 10.7270/Q2V40W83
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50318677 (4-Chloro-2-{[2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dih...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccc(O)cc1 Show InChI InChI=1S/C22H13ClN2O6/c23-12-2-8-16(22(30)31)18(10-12)24-19(27)11-1-7-15-17(9-11)21(29)25(20(15)28)13-3-5-14(26)6-4-13/h1-10,26H,(H,24,27)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.14E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells after 30 mins by malachite green method				J Med Chem 53: 5267-80 (2010) Article DOI: 10.1021/jm100442u BindingDB Entry DOI: 10.7270/Q2PV6MBN
					More data for this Ligand-Target Pair
Dynamin-1 (Rattus norvegicus)	BDBM50318674 (4-Chloro-2-{[2-(2-hydroxyphenyl)-1,3-dioxo-2,3-dih...) Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)c1ccc2C(=O)N(C(=O)c2c1)c1ccccc1O Show InChI InChI=1S/C22H13ClN2O6/c23-12-6-8-14(22(30)31)16(10-12)24-19(27)11-5-7-13-15(9-11)21(29)25(20(13)28)17-3-1-2-4-18(17)26/h1-10,26H,(H,24,27)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.19E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...				J Med Chem 53: 5267-80 (2010) Article DOI: 10.1021/jm100442u BindingDB Entry DOI: 10.7270/Q2PV6MBN
					More data for this Ligand-Target Pair
Dynamin-1 (Rattus norvegicus)	BDBM50318676 (4-Chloro-2-{[2-(4-hydroxymethylphenyl)-1,3-dioxo-2...) Show SMILES OCc1ccc(cc1)N1C(=O)c2ccc(cc2C1=O)C(=O)Nc1cc(Cl)ccc1C(O)=O Show InChI InChI=1S/C23H15ClN2O6/c24-14-4-8-17(23(31)32)19(10-14)25-20(28)13-3-7-16-18(9-13)22(30)26(21(16)29)15-5-1-12(11-27)2-6-15/h1-10,27H,11H2,(H,25,28)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...				J Med Chem 53: 5267-80 (2010) Article DOI: 10.1021/jm100442u BindingDB Entry DOI: 10.7270/Q2PV6MBN
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316539 (CHEMBL1094850 | N,N'-(Ethane-1,2-diyl)bis(7,8-dihy...) Show SMILES Oc1ccc2cc(C(=O)NCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O Show InChI InChI=1S/C22H18N4O8/c23-19-11(7-9-1-3-13(27)15(29)17(9)33-19)21(31)25-5-6-26-22(32)12-8-10-2-4-14(28)16(30)18(10)34-20(12)24/h1-4,7-8,23-24,27-30H,5-6H2,(H,25,31)(H,26,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+6	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair