| Reaction Details |
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 | Report a problem with these data |
| Target | Dynamin-2 |
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| Ligand | BDBM50316539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_631207 (CHEMBL1110056) |
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| IC50 | 1300000±n/a nM |
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| Citation |  Hill, TA; Mariana, A; Gordon, CP; Odell, LR; Robertson, MJ; McGeachie, AB; Chau, N; Daniel, JA; Gorgani, NN; Robinson, PJ; McCluskey, A Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J Med Chem53:4094-102 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dynamin-2 |
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| Name: | Dynamin-2 |
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| Synonyms: | DNM2 | DYN2 | DYN2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 98071.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_934670 |
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| Residue: | 870 |
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| Sequence: | MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPI
NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKL
QSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKL
KEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLID
IEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKE
YWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDL
RQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLV
DSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRD
DMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGR
PPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPP
GIPPGVPSRRPPAAPSRPTIIRPAEPSLLD
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| BDBM50316539 |
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| n/a |
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| Name | BDBM50316539 |
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| Synonyms: | CHEMBL1094850 | N,N'-(Ethane-1,2-diyl)bis(7,8-dihydroxy-2-imino-2H-chromene-3-carboxamide) |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18N4O8 |
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| Mol. Mass. | 466.4003 |
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| SMILES | Oc1ccc2cc(C(=O)NCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O |
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| Structure | 
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