Compile Data Set for Download or QSAR

Found 100 hits with Last Name = 'mcgeachie' and Initial = 'ab'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dynamin-2 (Homo sapiens (Human))	BDBM50316543 (CHEMBL1094197 | N,N'-(Propane-1,3-diyl)bis(6,7-dih...) Show SMILES Oc1cc2cc(C(=O)NCCCNC(=O)c3cc4cc(O)c(O)cc4oc3=N)c(=N)oc2cc1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(4-10-6-14(28)16(30)8-18(10)34-20)22(32)26-2-1-3-27-23(33)13-5-11-7-15(29)17(31)9-19(11)35-21(13)25/h4-9,24-25,28-31H,1-3H2,(H,26,32)(H,27,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316542 (CHEMBL1098764 | N,N'-(Propane-1,3-diyl)bis(7,8-dih...) Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(8-10-2-4-14(28)16(30)18(10)34-20)22(32)26-6-1-7-27-23(33)13-9-11-3-5-15(29)17(31)19(11)35-21(13)25/h2-5,8-9,24-25,28-31H,1,6-7H2,(H,26,32)(H,27,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316539 (CHEMBL1094850 | N,N'-(Ethane-1,2-diyl)bis(7,8-dihy...) Show SMILES Oc1ccc2cc(C(=O)NCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O Show InChI InChI=1S/C22H18N4O8/c23-19-11(7-9-1-3-13(27)15(29)17(9)33-19)21(31)25-5-6-26-22(32)12-8-10-2-4-14(28)16(30)18(10)34-20(12)24/h1-4,7-8,23-24,27-30H,5-6H2,(H,25,31)(H,26,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177941 (2-cyano-N-{3-[2-cyano-3-(3,4,5-trihydroxyphenyl)ac...) Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O Show InChI InChI=1S/C22H18N4O8/c23-9-13(3-11-5-15(27)19(31)16(28)6-11)21(33)25-1-2-26-22(34)14(10-24)4-12-7-17(29)20(32)18(30)8-12/h3-8,27-32H,1-2H2,(H,25,33)(H,26,34)/b13-3+,14-4+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177937 (2-cyano-N-{3-[2-cyano-3-(3,4,5-trihydroxyphenyl)ac...) Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O Show InChI InChI=1S/C23H20N4O8/c24-10-14(4-12-6-16(28)20(32)17(29)7-12)22(34)26-2-1-3-27-23(35)15(11-25)5-13-8-18(30)21(33)19(31)9-13/h4-9,28-33H,1-3H2,(H,26,34)(H,27,35)/b14-4+,15-5+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177923 (2-cyano-N-{3-[2-cyano-3-(3,4,5-trihydroxyphenyl)ac...) Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O Show InChI InChI=1S/C25H24N4O8/c26-12-16(6-14-8-18(30)22(34)19(31)9-14)24(36)28-4-2-1-3-5-29-25(37)17(13-27)7-15-10-20(32)23(35)21(33)11-15/h6-11,30-35H,1-5H2,(H,28,36)(H,29,37)/b16-6+,17-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM5149 ((2E)-2-cyano-N-{3-[(2E)-2-cyano-3-(3,4-dihydroxyph...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O Show InChI InChI=1S/C23H20N4O6/c24-12-16(8-14-2-4-18(28)20(30)10-14)22(32)26-6-1-7-27-23(33)17(13-25)9-15-3-5-19(29)21(31)11-15/h2-5,8-11,28-31H,1,6-7H2,(H,26,32)(H,27,33)/b16-8+,17-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM5152 ((2E)-2-cyano-N-{4-[(2E)-2-cyano-3-(3,4,5-trihydrox...) Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O Show InChI InChI=1S/C24H22N4O8/c25-11-15(5-13-7-17(29)21(33)18(30)8-13)23(35)27-3-1-2-4-28-24(36)16(12-26)6-14-9-19(31)22(34)20(32)10-14/h5-10,29-34H,1-4H2,(H,27,35)(H,28,36)/b15-5+,16-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM5151 ((2E)-2-cyano-N-{4-[(2E)-2-cyano-3-(3,4-dihydroxyph...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O Show InChI InChI=1S/C24H22N4O6/c25-13-17(9-15-3-5-19(29)21(31)11-15)23(33)27-7-1-2-8-28-24(34)18(14-26)10-16-4-6-20(30)22(32)12-16/h3-6,9-12,29-32H,1-2,7-8H2,(H,27,33)(H,28,34)/b17-9+,18-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177943 (2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxy-5-methoxyph...) Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O Show InChI InChI=1S/C25H24N4O8/c1-36-20-10-14(8-18(30)22(20)32)6-16(12-26)24(34)28-4-3-5-29-25(35)17(13-27)7-15-9-19(31)23(33)21(11-15)37-2/h6-11,30-33H,3-5H2,1-2H3,(H,28,34)(H,29,35)/b16-6+,17-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50268295 (2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-in...) Show SMILES CCCCCCCCNC(=O)C(=C\c1cn(CCCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C25H36N4O/c1-4-5-6-7-8-11-15-27-25(30)21(19-26)18-22-20-29(17-12-16-28(2)3)24-14-10-9-13-23(22)24/h9-10,13-14,18,20H,4-8,11-12,15-17H2,1-3H3,(H,27,30)/b21-18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins				J Med Chem 52: 3762-73 (2009) Article DOI: 10.1021/jm900036m BindingDB Entry DOI: 10.7270/Q28W3D79
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM5153 ((2E)-2-cyano-N-{5-[(2E)-2-cyano-3-(3,4-dihydroxyph...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O Show InChI InChI=1S/C25H24N4O6/c26-14-18(10-16-4-6-20(30)22(32)12-16)24(34)28-8-2-1-3-9-29-25(35)19(15-27)11-17-5-7-21(31)23(33)13-17/h4-7,10-13,30-33H,1-3,8-9H2,(H,28,34)(H,29,35)/b18-10+,19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177940 (2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxyphenyl)acryl...) Show SMILES OC(CNC(=O)C(=C\c1ccc(O)c(O)c1)\C#N)CNC(=O)C(=C\c1ccc(O)c(O)c1)\C#N Show InChI InChI=1S/C23H20N4O7/c24-9-15(5-13-1-3-18(29)20(31)7-13)22(33)26-11-17(28)12-27-23(34)16(10-25)6-14-2-4-19(30)21(32)8-14/h1-8,17,28-32H,11-12H2,(H,26,33)(H,27,34)/b15-5+,16-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM5150 ((2E)-2-cyano-N-{2-[(2E)-2-cyano-3-(3,4-dihydroxyph...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O Show InChI InChI=1S/C22H18N4O6/c23-11-15(7-13-1-3-17(27)19(29)9-13)21(31)25-5-6-26-22(32)16(12-24)8-14-2-4-18(28)20(30)10-14/h1-4,7-10,27-30H,5-6H2,(H,25,31)(H,26,32)/b15-7+,16-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177965 (2-cyano-N-{3-[-2-cyano-3-(3,4,5-trihydroxyphenyl)a...) Show SMILES Oc1cc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2cc(O)c(O)c(O)c2)\C#N)cc(O)c1O Show InChI InChI=1S/C26H26N4O8/c27-13-17(7-15-9-19(31)23(35)20(32)10-15)25(37)29-5-3-1-2-4-6-30-26(38)18(14-28)8-16-11-21(33)24(36)22(34)12-16/h7-12,31-36H,1-6H2,(H,29,37)(H,30,38)/b17-7+,18-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177944 (2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxy-5-methoxyph...) Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O Show InChI InChI=1S/C27H28N4O8/c1-38-22-12-16(10-20(32)24(22)34)8-18(14-28)26(36)30-6-4-3-5-7-31-27(37)19(15-29)9-17-11-21(33)25(35)23(13-17)39-2/h8-13,32-35H,3-7H2,1-2H3,(H,30,36)(H,31,37)/b18-8+,19-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177973 (2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxy-5-methoxyph...) Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O Show InChI InChI=1S/C26H26N4O8/c1-37-21-11-15(9-19(31)23(21)33)7-17(13-27)25(35)29-5-3-4-6-30-26(36)18(14-28)8-16-10-20(32)24(34)22(12-16)38-2/h7-12,31-34H,3-6H2,1-2H3,(H,29,35)(H,30,36)/b17-7+,18-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177955 (2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxy-5-methoxyph...) Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O Show InChI InChI=1S/C24H22N4O8/c1-35-19-9-13(7-17(29)21(19)31)5-15(11-25)23(33)27-3-4-28-24(34)16(12-26)6-14-8-18(30)22(32)20(10-14)36-2/h5-10,29-32H,3-4H2,1-2H3,(H,27,33)(H,28,34)/b15-5+,16-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316542 (CHEMBL1098764 | N,N'-(Propane-1,3-diyl)bis(7,8-dih...) Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(8-10-2-4-14(28)16(30)18(10)34-20)22(32)26-6-1-7-27-23(33)13-9-11-3-5-15(29)17(31)19(11)35-21(13)25/h2-5,8-9,24-25,28-31H,1,6-7H2,(H,26,32)(H,27,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.07E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50268962 (2-Cyano-N-octyl-3-[1-(3-dimethylaminopropyl)-2-met...) Show SMILES CCCCCCCCNC(=O)C(=C\c1c(C)n(CCCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C26H38N4O/c1-5-6-7-8-9-12-16-28-26(31)22(20-27)19-24-21(2)30(18-13-17-29(3)4)25-15-11-10-14-23(24)25/h10-11,14-15,19H,5-9,12-13,16-18H2,1-4H3,(H,28,31)/b22-19+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins				J Med Chem 52: 3762-73 (2009) Article DOI: 10.1021/jm900036m BindingDB Entry DOI: 10.7270/Q28W3D79
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50268872 (2-Cyano-N-octyl-3-[1-(2-dimethylaminoethyl)-2-meth...) Show SMILES CCCCCCCCNC(=O)C(=C\c1c(C)n(CCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C25H36N4O/c1-5-6-7-8-9-12-15-27-25(30)21(19-26)18-23-20(2)29(17-16-28(3)4)24-14-11-10-13-22(23)24/h10-11,13-14,18H,5-9,12,15-17H2,1-4H3,(H,27,30)/b21-18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins				J Med Chem 52: 3762-73 (2009) Article DOI: 10.1021/jm900036m BindingDB Entry DOI: 10.7270/Q28W3D79
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50268961 (2-Cyano-N-hexyl-3-[1-(3-dimethylaminopropyl)-2-met...) Show SMILES CCCCCCNC(=O)C(=C\c1c(C)n(CCCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C24H34N4O/c1-5-6-7-10-14-26-24(29)20(18-25)17-22-19(2)28(16-11-15-27(3)4)23-13-9-8-12-21(22)23/h8-9,12-13,17H,5-7,10-11,14-16H2,1-4H3,(H,26,29)/b20-17+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins				J Med Chem 52: 3762-73 (2009) Article DOI: 10.1021/jm900036m BindingDB Entry DOI: 10.7270/Q28W3D79
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316541 (CHEMBL1096801 | N,N'-(Propane-1,3-diyl)bis(7-hydro...) Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)cc4oc3=N)c(=N)oc2c1 Show InChI InChI=1S/C23H20N4O6/c24-20-16(8-12-2-4-14(28)10-18(12)32-20)22(30)26-6-1-7-27-23(31)17-9-13-3-5-15(29)11-19(13)33-21(17)25/h2-5,8-11,24-25,28-29H,1,6-7H2,(H,26,30)(H,27,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.67E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM5154 ((2E)-2-cyano-N-{6-[(2E)-2-cyano-3-(3,4-dihydroxyph...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O Show InChI InChI=1S/C26H26N4O6/c27-15-19(11-17-5-7-21(31)23(33)13-17)25(35)29-9-3-1-2-4-10-30-26(36)20(16-28)12-18-6-8-22(32)24(34)14-18/h5-8,11-14,31-34H,1-4,9-10H2,(H,29,35)(H,30,36)/b19-11+,20-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316540 (CHEMBL1098763 | N,N'-(Propane-1,3-diyl)bis(8-hydro...) Show SMILES Oc1cccc2cc(C(=O)NCCCNC(=O)c3cc4cccc(O)c4oc3=N)c(=N)oc12 Show InChI InChI=1S/C23H20N4O6/c24-20-14(10-12-4-1-6-16(28)18(12)32-20)22(30)26-8-3-9-27-23(31)15-11-13-5-2-7-17(29)19(13)33-21(15)25/h1-2,4-7,10-11,24-25,28-29H,3,8-9H2,(H,26,30)(H,27,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.48E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of recombinant dynamin 2 expressed in Sf9 cells by malachite green GTPase assay				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177950 (2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-c...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCOC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O Show InChI InChI=1S/C23H18N2O8/c24-12-16(8-14-2-4-18(26)20(28)10-14)22(30)32-6-1-7-33-23(31)17(13-25)9-15-3-5-19(27)21(29)11-15/h2-5,8-11,26-29H,1,6-7H2/b16-8+,17-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Rattus norvegicus)	BDBM50316543 (CHEMBL1094197 | N,N'-(Propane-1,3-diyl)bis(6,7-dih...) Show SMILES Oc1cc2cc(C(=O)NCCCNC(=O)c3cc4cc(O)c(O)cc4oc3=N)c(=N)oc2cc1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(4-10-6-14(28)16(30)8-18(10)34-20)22(32)26-2-1-3-27-23(33)13-5-11-7-15(29)17(31)9-19(11)35-21(13)25/h4-9,24-25,28-31H,1-3H2,(H,26,32)(H,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177970 (2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-c...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCOC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O Show InChI InChI=1S/C22H16N2O8/c23-11-15(7-13-1-3-17(25)19(27)9-13)21(29)31-5-6-32-22(30)16(12-24)8-14-2-4-18(26)20(28)10-14/h1-4,7-10,25-28H,5-6H2/b15-7+,16-8+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316540 (CHEMBL1098763 | N,N'-(Propane-1,3-diyl)bis(8-hydro...) Show SMILES Oc1cccc2cc(C(=O)NCCCNC(=O)c3cc4cccc(O)c4oc3=N)c(=N)oc12 Show InChI InChI=1S/C23H20N4O6/c24-20-14(10-12-4-1-6-16(28)18(12)32-20)22(30)26-8-3-9-27-23(31)15-11-13-5-2-7-17(29)19(13)33-21(15)25/h1-2,4-7,10-11,24-25,28-29H,3,8-9H2,(H,26,30)(H,27,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50268963 (2-Cyano-N-decyl-3-[1-(2-dimethylaminoethyl)-2-meth...) Show SMILES CCCCCCCCCCNC(=O)C(=C\c1c(C)n(CCN(C)C)c2ccccc12)\C#N Show InChI InChI=1S/C27H40N4O/c1-5-6-7-8-9-10-11-14-17-29-27(32)23(21-28)20-25-22(2)31(19-18-30(3)4)26-16-13-12-15-24(25)26/h12-13,15-16,20H,5-11,14,17-19H2,1-4H3,(H,29,32)/b23-20+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated endocytosis internalization of Tf-A594 in human U2OS cells pretreated for 30 mins				J Med Chem 52: 3762-73 (2009) Article DOI: 10.1021/jm900036m BindingDB Entry DOI: 10.7270/Q28W3D79
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177915 (2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid 2-[2-c...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)OCCCCOC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O Show InChI InChI=1S/C24H20N2O8/c25-13-17(9-15-3-5-19(27)21(29)11-15)23(31)33-7-1-2-8-34-24(32)18(14-26)10-16-4-6-20(28)22(30)12-16/h3-6,9-12,27-30H,1-2,7-8H2/b17-9+,18-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Rattus norvegicus)	BDBM50316541 (CHEMBL1096801 | N,N'-(Propane-1,3-diyl)bis(7-hydro...) Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)cc4oc3=N)c(=N)oc2c1 Show InChI InChI=1S/C23H20N4O6/c24-20-16(8-12-2-4-14(28)10-18(12)32-20)22(30)26-6-1-7-27-23(31)17-9-13-3-5-15(29)11-19(13)33-21(17)25/h2-5,8-11,24-25,28-29H,1,6-7H2,(H,26,30)(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.61E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM4363 ((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...) Show SMILES NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N Show InChI InChI=1S/C10H8N2O2S/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-2 (Homo sapiens (Human))	BDBM50316543 (CHEMBL1094197 | N,N'-(Propane-1,3-diyl)bis(6,7-dih...) Show SMILES Oc1cc2cc(C(=O)NCCCNC(=O)c3cc4cc(O)c(O)cc4oc3=N)c(=N)oc2cc1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(4-10-6-14(28)16(30)8-18(10)34-20)22(32)26-2-1-3-27-23(33)13-5-11-7-15(29)17(31)9-19(11)35-21(13)25/h4-9,24-25,28-31H,1-3H2,(H,26,32)(H,27,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.46E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 2-mediated receptor-induced endocytosis in human U2OS cells assessed as uptake of Tf-TxR dye after 30 mins by automated acquisi...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177930 (2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxy-5-methoxyph...) Show SMILES COc1cc(\C=C(/C#N)C(=O)NCCCCCCNC(=O)C(=C\c2cc(O)c(O)c(OC)c2)\C#N)cc(O)c1O Show InChI InChI=1S/C28H30N4O8/c1-39-23-13-17(11-21(33)25(23)35)9-19(15-29)27(37)31-7-5-3-4-6-8-32-28(38)20(16-30)10-18-12-22(34)26(36)24(14-18)40-2/h9-14,33-36H,3-8H2,1-2H3,(H,31,37)(H,32,38)/b19-9+,20-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM5156 ((2E)-2-cyano-N-[(3-{[(2E)-2-cyano-3-(3,4-dihydroxy...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCc2cccc(CNC(=O)C(=C\c3ccc(O)c(O)c3)\C#N)c2)cc1O Show InChI InChI=1S/C28H22N4O6/c29-13-21(9-17-4-6-23(33)25(35)11-17)27(37)31-15-19-2-1-3-20(8-19)16-32-28(38)22(14-30)10-18-5-7-24(34)26(36)12-18/h1-12,33-36H,15-16H2,(H,31,37)(H,32,38)/b21-9+,22-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177951 (2-cyano-N-{3-[2-cyano-3-(3,4-dihydroxyphenyl)acryl...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)N[C@H]2CCCC[C@@H]2NC(=O)C(=C\c2ccc(O)c(O)c2)\C#N)cc1O Show InChI InChI=1S/C26H24N4O6/c27-13-17(9-15-5-7-21(31)23(33)11-15)25(35)29-19-3-1-2-4-20(19)30-26(36)18(14-28)10-16-6-8-22(32)24(34)12-16/h5-12,19-20,31-34H,1-4H2,(H,29,35)(H,30,36)/b17-9+,18-10+/t19-,20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Rattus norvegicus)	BDBM50316542 (CHEMBL1098764 | N,N'-(Propane-1,3-diyl)bis(7,8-dih...) Show SMILES Oc1ccc2cc(C(=O)NCCCNC(=O)c3cc4ccc(O)c(O)c4oc3=N)c(=N)oc2c1O Show InChI InChI=1S/C23H20N4O8/c24-20-12(8-10-2-4-14(28)16(30)18(10)34-20)22(32)26-6-1-7-27-23(33)13-9-11-3-5-15(29)17(31)19(11)35-21(13)25/h2-5,8-9,24-25,28-31H,1,6-7H2,(H,26,32)(H,27,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9.95E+4	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibition of dynamin 1-mediated synaptic vesicle endocytosis in Sprague-Dawley rat synaptosomes assessed as uptake of FM 4-64 dye after 30 mins by a...				J Med Chem 53: 4094-102 (2010) Article DOI: 10.1021/jm100119c BindingDB Entry DOI: 10.7270/Q2PZ5903
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177933 (2-cyano-N-{5-[2-cyano-3-(3-hydroxyphenyl)acryloyla...) Show SMILES Oc1cccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2cccc(O)c2)\C#N)c1 Show InChI InChI=1S/C25H24N4O4/c26-16-20(12-18-6-4-8-22(30)14-18)24(32)28-10-2-1-3-11-29-25(33)21(17-27)13-19-7-5-9-23(31)15-19/h4-9,12-15,30-31H,1-3,10-11H2,(H,28,32)(H,29,33)/b20-12+,21-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177934 (2-cyano-N-{3-[2-cyano-3-(3-methoxyphenyl)acryloyla...) Show SMILES COc1cccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2cccc(OC)c2)\C#N)c1 Show InChI InChI=1S/C25H24N4O4/c1-32-22-8-3-6-18(14-22)12-20(16-26)24(30)28-10-5-11-29-25(31)21(17-27)13-19-7-4-9-23(15-19)33-2/h3-4,6-9,12-15H,5,10-11H2,1-2H3,(H,28,30)(H,29,31)/b20-12+,21-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177938 (2-cyano-N-{4-[2-cyano-3-(3-hydroxy-4-methoxyphenyl...) Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCCCNC(=O)C(=C\c2ccc(OC)c(O)c2)\C#N)cc1O Show InChI InChI=1S/C26H26N4O6/c1-35-23-7-5-17(13-21(23)31)11-19(15-27)25(33)29-9-3-4-10-30-26(34)20(16-28)12-18-6-8-24(36-2)22(32)14-18/h5-8,11-14,31-32H,3-4,9-10H2,1-2H3,(H,29,33)(H,30,34)/b19-11+,20-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177942 (2-cyano-N-{2-[2-cyano-3-(3-methoxyphenyl)acryloyla...) Show SMILES COc1cccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2cccc(OC)c2)\C#N)c1 Show InChI InChI=1S/C24H22N4O4/c1-31-21-7-3-5-17(13-21)11-19(15-25)23(29)27-9-10-28-24(30)20(16-26)12-18-6-4-8-22(14-18)32-2/h3-8,11-14H,9-10H2,1-2H3,(H,27,29)(H,28,30)/b19-11+,20-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177945 (2-cyano-N-{3-[2-cyano-3-(4-hydroxyphenyl)acryloyla...) Show SMILES Oc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(O)cc2)\C#N)cc1 Show InChI InChI=1S/C23H20N4O4/c24-14-18(12-16-2-6-20(28)7-3-16)22(30)26-10-1-11-27-23(31)19(15-25)13-17-4-8-21(29)9-5-17/h2-9,12-13,28-29H,1,10-11H2,(H,26,30)(H,27,31)/b18-12+,19-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177939 (2-cyano-N-{3-[2-cyano-3-(3-hydroxyphenyl)acryloyla...) Show SMILES Oc1cccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2cccc(O)c2)\C#N)c1 Show InChI InChI=1S/C23H20N4O4/c24-14-18(10-16-4-1-6-20(28)12-16)22(30)26-8-3-9-27-23(31)19(15-25)11-17-5-2-7-21(29)13-17/h1-2,4-7,10-13,28-29H,3,8-9H2,(H,26,30)(H,27,31)/b18-10+,19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177947 (2-cyano-N-(3-{[2-cyano-3-(3,4-dihydroxyphenyl)acry...) Show SMILES CN(CCCN(C)C(=O)C(=C\c1ccc(O)c(O)c1)\C#N)C(=O)C(=C\c1ccc(O)c(O)c1)\C#N Show InChI InChI=1S/C25H24N4O6/c1-28(24(34)18(14-26)10-16-4-6-20(30)22(32)12-16)8-3-9-29(2)25(35)19(15-27)11-17-5-7-21(31)23(33)13-17/h4-7,10-13,30-33H,3,8-9H2,1-2H3/b18-10+,19-11+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177948 (2-cyano-N-[6-(2-cyano-3-phenylacryloylamino)hexyl]...) Show SMILES O=C(NCCCCCCNC(=O)C(=C\c1ccccc1)\C#N)C(=C\c1ccccc1)\C#N Show InChI InChI=1S/C26H26N4O2/c27-19-23(17-21-11-5-3-6-12-21)25(31)29-15-9-1-2-10-16-30-26(32)24(20-28)18-22-13-7-4-8-14-22/h3-8,11-14,17-18H,1-2,9-10,15-16H2,(H,29,31)(H,30,32)/b23-17+,24-18+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177949 (3-(4-chlorophenyl)-N-{5-[3-(4-chlorophenyl)-2-cyan...) Show SMILES Clc1cccc(\C=C(/C#N)C(=O)NCCCCCNC(=O)C(=C\c2cccc(Cl)c2)\C#N)c1 Show InChI InChI=1S/C25H22Cl2N4O2/c26-22-8-4-6-18(14-22)12-20(16-28)24(32)30-10-2-1-3-11-31-25(33)21(17-29)13-19-7-5-9-23(27)15-19/h4-9,12-15H,1-3,10-11H2,(H,30,32)(H,31,33)/b20-12+,21-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177946 (2-cyano-N-[2-(2-cyano-3-phenylacryloylamino)ethyl]...) Show SMILES O=C(NCCNC(=O)C(=C\c1ccccc1)\C#N)C(=C\c1ccccc1)\C#N Show InChI InChI=1S/C22H18N4O2/c23-15-19(13-17-7-3-1-4-8-17)21(27)25-11-12-26-22(28)20(16-24)14-18-9-5-2-6-10-18/h1-10,13-14H,11-12H2,(H,25,27)(H,26,28)/b19-13+,20-14+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177952 (3-(4-chlorophenyl)-N-{3-[3-(4-chlorophenyl)-2-cyan...) Show SMILES Clc1ccc(\C=C(/C#N)C(=O)NCCCNC(=O)C(=C\c2ccc(Cl)cc2)\C#N)cc1 Show InChI InChI=1S/C23H18Cl2N4O2/c24-20-6-2-16(3-7-20)12-18(14-26)22(30)28-10-1-11-29-23(31)19(15-27)13-17-4-8-21(25)9-5-17/h2-9,12-13H,1,10-11H2,(H,28,30)(H,29,31)/b18-12+,19-13+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair
Dynamin-1 (Homo sapiens (Human))	BDBM50177953 (2-cyano-N-{2-[2-cyano-3-(3,4-dimethoxyphenyl)acryl...) Show SMILES COc1ccc(\C=C(/C#N)C(=O)NCCNC(=O)C(=C\c2ccc(OC)c(OC)c2)\C#N)cc1OC Show InChI InChI=1S/C26H26N4O6/c1-33-21-7-5-17(13-23(21)35-3)11-19(15-27)25(31)29-9-10-30-26(32)20(16-28)12-18-6-8-22(34-2)24(14-18)36-4/h5-8,11-14H,9-10H2,1-4H3,(H,29,31)(H,30,32)/b19-11+,20-12+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
The University of Newcastle Curated by ChEMBL					Assay Description Inhibitory activity against dynamin1 GTPase expressed in sheep brain				J Med Chem 48: 7781-8 (2005) Article DOI: 10.1021/jm040208l BindingDB Entry DOI: 10.7270/Q2BC3Z41
					More data for this Ligand-Target Pair

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