| Reaction Details |
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 | Report a problem with these data |
| Target | Dynamin-2 |
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| Ligand | BDBM50268295 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_934670 (CHEMBL2318140) |
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| IC50 | 5000±n/a nM |
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| Citation |  Gordon, CP; Venn-Brown, B; Robertson, MJ; Young, KA; Chau, N; Mariana, A; Whiting, A; Chircop, M; Robinson, PJ; McCluskey, A Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem56:46-59 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dynamin-2 |
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| Name: | Dynamin-2 |
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| Synonyms: | DNM2 | DYN2 | DYN2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 98071.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_934670 |
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| Residue: | 870 |
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| Sequence: | MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPI
NLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMD
LANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKL
QSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGA
RINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKL
KEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLID
IEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKE
YWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDL
RQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLV
DSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRD
DMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGR
PPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPP
GIPPGVPSRRPPAAPSRPTIIRPAEPSLLD
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| BDBM50268295 |
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| n/a |
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| Name | BDBM50268295 |
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| Synonyms: | 2-Cyano-N-octyl-3-(1-(3-dimethylaminopropyl)-1H-indol-3-yl)-acrylamide | CHEMBL483059 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H36N4O |
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| Mol. Mass. | 408.5795 |
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| SMILES | CCCCCCCCNC(=O)C(=C\c1cn(CCCN(C)C)c2ccccc12)\C#N |
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| Structure | 
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