Reaction Details |
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Target | Kappa-type opioid receptor |
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Ligand | BDBM50330441 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_684921 (CHEMBL1286336) |
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IC50 | >1000±n/a nM |
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Citation | Asagarasu, A; Matsui, T; Hayashi, H; Tamaoki, S; Yamauchi, Y; Minato, K; Sato, M Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome. J Med Chem53:7549-63 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kappa-type opioid receptor |
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Name: | Kappa-type opioid receptor |
Synonyms: | Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 42744.99 |
Organism: | Cavia porcellus (domestic guinea pig) |
Description: | P41144 |
Residue: | 380 |
Sequence: | MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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BDBM50330441 |
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n/a |
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Name | BDBM50330441 |
Synonyms: | 3-amino-2-(4-(4-(quinolin-2-yl)piperazin-1-yl)butyl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one | CHEMBL1278088 |
Type | Small organic molecule |
Emp. Form. | C25H32N6O |
Mol. Mass. | 432.5612 |
SMILES | Nn1c(CCCCN2CCN(CC2)c2ccc3ccccc3n2)nc2CCCCc2c1=O |
Structure |
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