Reaction Details |
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Target | Aurora kinase B |
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Ligand | BDBM50335330 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_701579 (CHEMBL1656338) |
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IC50 | >100000±n/a nM |
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Citation | Prime, ME; Courtney, SM; Brookfield, FA; Marston, RW; Walker, V; Warne, J; Boyd, AE; Kairies, NA; von der Saal, W; Limberg, A; Georges, G; Engh, RA; Goller, B; Rueger, P; Rueth, M Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase. J Med Chem54:312-9 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase B |
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Name: | Aurora kinase B |
Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
Type: | Protein |
Mol. Mass.: | 39327.72 |
Organism: | Homo sapiens (Human) |
Description: | Q96GD4 |
Residue: | 344 |
Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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BDBM50335330 |
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n/a |
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Name | BDBM50335330 |
Synonyms: | 4-(5-Methyl-2H-pyrazole-3-ylamino)phenyl-2H-phthalazin-1-one | 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1(2H)-one | CHEMBL1615165 |
Type | Small organic molecule |
Emp. Form. | C18H15N5O |
Mol. Mass. | 317.3446 |
SMILES | Cc1cc(Nc2nn(-c3ccccc3)c(=O)c3ccccc23)[nH]n1 |
Structure |
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