| Reaction Details |
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 | Report a problem with these data |
| Target | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Ligand | BDBM50335485 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_702118 (CHEMBL1655348) |
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| IC50 | 119±n/a nM |
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| Citation |  Deng, L; Endo, K; Kato, M; Cheng, G; Yajima, S; Song, Y Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes. ACS Med Chem Lett2:165-170 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Name: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase |
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| Synonyms: | 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXP) | 1-Deoxyxylulose 5-phosphate reductoisomerase (DXR) | 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) | 2-C-methyl-D-erythritol 4-phosphate synthase | DXP reductoisomerase | DXR_ECOLI | dxr | ispC | yaeM |
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| Type: | Protein |
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| Mol. Mass.: | 43384.52 |
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| Organism: | Escherichia coli |
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| Description: | P45568 |
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| Residue: | 398 |
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| Sequence: | MKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVTRMVEQCLEFSPRYAVMDDEA
SAKLLKTMLQQQGSRTEVLSGQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTI
LLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSLPQPIQHNLGYADLEQNGVVS
ILLTGSGGPFRETPLRDLATMTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
ASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPIAHTMAWPNRVNSGVKPLDFC
KLSALTFAAPDYDRYPCLKLAMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN
LSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS
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| BDBM50335485 |
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| n/a |
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| Name | BDBM50335485 |
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| Synonyms: | (R)-1-(3,4-dichlorophenyl)-3-(N-hydroxyacetamido)propylphosphonic acid | CHEMBL1651836 | [(1R)-3-[acetyl(hydroxy)amino]-1-(3,4-dichlorophenyl)propyl]phosphonic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C11H14Cl2NO5P |
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| Mol. Mass. | 342.112 |
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| SMILES | CC(=O)N(O)CC[C@H](c1ccc(Cl)c(Cl)c1)P(O)(O)=O |r| |
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| Structure | 
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