| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-dependent RNA helicase DDX1 |
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| Ligand | BDBM50379304 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_811952 (CHEMBL2013322) |
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| IC50 | >500000±n/a nM |
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| Citation |  Radi, M; Falchi, F; Garbelli, A; Samuele, A; Bernardo, V; Paolucci, S; Baldanti, F; Schenone, S; Manetti, F; Maga, G; Botta, M Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors. Bioorg Med Chem Lett22:2094-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-dependent RNA helicase DDX1 |
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| Name: | ATP-dependent RNA helicase DDX1 |
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| Synonyms: | DBP-RB | DDX1 | DDX1_HUMAN | DEAD box protein 1 | DEAD box protein retinoblastoma |
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| Type: | PROTEIN |
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| Mol. Mass.: | 82440.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_811952 |
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| Residue: | 740 |
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| Sequence: | MAAFSEMGVMPEIAQAVEEMDWLLPTDIQAESIPLILGGGDVLMAAETGSGKTGAFSIPV
IQIVYETLKDQQEGKKGKTTIKTGASVLNKWQMNPYDRGSAFAIGSDGLCCQSREVKEWH
GCRATKGLMKGKHYYEVSCHDQGLCRVGWSTMQASLDLGTDKFGFGFGGTGKKSHNKQFD
NYGEEFTMHDTIGCYLDIDKGHVKFSKNGKDLGLAFEIPPHMKNQALFPACVLKNAELKF
NFGEEEFKFPPKDGFVALSKAPDGYIVKSQHSGNAQVTQTKFLPNAPKALIVEPSRELAE
QTLNNIKQFKKYIDNPKLRELLIIGGVAARDQLSVLENGVDIVVGTPGRLDDLVSTGKLN
LSQVRFLVLDEADGLLSQGYSDFINRMHNQIPQVTSDGKRLQVIVCSATLHSFDVKKLSE
KIMHFPTWVDLKGEDSVPDTVHHVVVPVNPKTDRLWERLGKSHIRTDDVHAKDNTRPGAN
SPEMWSEAIKILKGEYAVRAIKEHKMDQAIIFCRTKIDCDNLEQYFIQQGGGPDKKGHQF
SCVCLHGDRKPHERKQNLERFKKGDVRFLICTDVAARGIDIHGVPYVINVTLPDEKQNYV
HRIGRVGRAERMGLAISLVATEKEKVWYHVCSSRGKGCYNTRLKEDGGCTIWYNEMQLLS
EIEEHLNCTISQVEPDIKVPVDEFDGKVTYGQKRAAGGGSYKGHVDILAPTVQELAALEK
EAQTSFLHLGYLPNQLFRTF
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| BDBM50379304 |
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| n/a |
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| Name | BDBM50379304 |
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| Synonyms: | CHEMBL2011805 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15N3O2 |
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| Mol. Mass. | 353.3734 |
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| SMILES | O=C(Nc1ccc(cc1)-c1nc2ccccc2[nH]1)c1cc2ccccc2o1 |
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| Structure | 
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