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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50380028 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_810739 (CHEMBL2015972) | ||
| IC50 | 590±n/a nM | ||
| Citation |  Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett22:2497-502 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50380028 | |||
| n/a | |||
| Name | BDBM50380028 | ||
| Synonyms: | CHEMBL2012608 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H27N3O3S | ||
| Mol. Mass. | 449.565 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(CCc2ccccc2)s1 |r,wU:7.10,wD:4.3,(41.1,-9.44,;39.56,-9.46,;38.8,-10.8,;38.77,-8.13,;37.23,-8.15,;36.44,-6.83,;34.9,-6.85,;34.15,-8.19,;34.93,-9.51,;36.47,-9.5,;32.62,-8.21,;31.83,-6.89,;30.3,-6.92,;29.55,-8.25,;30.32,-9.57,;31.87,-9.55,;28.01,-8.26,;27.22,-6.94,;27.25,-9.61,;25.71,-9.62,;24.79,-8.39,;23.33,-8.88,;23.35,-10.42,;22.01,-11.18,;20.68,-10.39,;19.34,-11.15,;18.02,-10.36,;16.68,-11.11,;16.66,-12.66,;17.99,-13.44,;19.33,-12.68,;24.82,-10.88,)| | ||
| Structure | 
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