Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50380030 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_810738 (CHEMBL2015971) | ||
| IC50 | 728±n/a nM | ||
| Citation |  Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett22:2497-502 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
| ||
| BDBM50380030 | |||
| n/a | |||
| Name | BDBM50380030 | ||
| Synonyms: | CHEMBL2012626 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H27N3O4S | ||
| Mol. Mass. | 465.565 | ||
| SMILES | COc1ccc(Cc2nnc(NC(=O)c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)s2)cc1 |r,wU:20.20,wD:23.24,(-7.01,3.75,;-7.02,2.21,;-5.7,1.43,;-4.35,2.18,;-3.03,1.4,;-3.05,-.14,;-1.73,-.93,;-.38,-.17,;-.4,1.37,;1.06,1.86,;1.98,.63,;3.52,.65,;4.28,1.99,;3.49,3.31,;5.82,2,;6.56,3.34,;8.1,3.36,;8.88,2.04,;8.14,.7,;6.59,.68,;10.42,2.06,;11.17,3.4,;12.71,3.43,;13.5,2.1,;15.04,2.12,;15.82,.8,;17.36,.82,;15.07,-.55,;12.74,.75,;11.2,.74,;1.09,-.63,;-4.38,-.9,;-5.71,-.12,)| | ||
| Structure | 
| ||