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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50380038 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_810738 (CHEMBL2015971) | ||
| IC50 | 5280±n/a nM | ||
| Citation |  Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett22:2497-502 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50380038 | |||
| n/a | |||
| Name | BDBM50380038 | ||
| Synonyms: | CHEMBL2012630 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H24ClN3O3S | ||
| Mol. Mass. | 469.984 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(Cc2ccc(Cl)cc2)s1 |r,wU:7.10,wD:4.3,(15.13,-16.75,;13.59,-16.77,;12.84,-18.12,;12.8,-15.45,;11.26,-15.47,;10.47,-14.14,;8.94,-14.17,;8.19,-15.51,;8.97,-16.83,;10.5,-16.82,;6.65,-15.53,;5.87,-14.21,;4.33,-14.23,;3.58,-15.57,;4.36,-16.89,;5.9,-16.87,;2.04,-15.58,;1.26,-14.26,;1.29,-16.92,;-.25,-16.94,;-1.17,-15.71,;-2.63,-16.2,;-2.62,-17.74,;-3.96,-18.5,;-5.28,-17.71,;-5.26,-16.17,;-6.59,-15.39,;-7.93,-16.14,;-9.26,-15.36,;-7.94,-17.69,;-6.62,-18.47,;-1.15,-18.2,)| | ||
| Structure | 
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