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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50380044 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_810738 (CHEMBL2015971) | ||
| IC50 | 24±n/a nM | ||
| Citation |  Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett22:2497-502 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50380044 | |||
| n/a | |||
| Name | BDBM50380044 | ||
| Synonyms: | CHEMBL2012614 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H29N3O3S | ||
| Mol. Mass. | 427.56 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(CC2CCCC2)s1 |r,wU:7.10,wD:4.3,(41.54,-33.26,;40,-33.28,;39.25,-34.62,;39.22,-31.95,;37.68,-31.97,;36.89,-30.65,;35.35,-30.67,;34.6,-32.02,;35.38,-33.34,;36.92,-33.32,;33.07,-32.03,;32.28,-30.72,;30.75,-30.74,;30,-32.07,;30.77,-33.39,;32.32,-33.37,;28.46,-32.09,;27.67,-30.76,;27.7,-33.43,;26.16,-33.45,;25.24,-32.21,;23.78,-32.7,;23.8,-34.24,;22.46,-35,;21.24,-34.06,;21.28,-32.52,;19.83,-32,;18.89,-33.22,;19.76,-34.49,;25.27,-34.7,)| | ||
| Structure | 
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