Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50380047 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_810738 (CHEMBL2015971) | ||
IC50 | 30±n/a nM | ||
Citation | Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett22:2497-502 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50380047 | |||
n/a | |||
Name | BDBM50380047 | ||
Synonyms: | CHEMBL2012631 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H24ClN3O3S | ||
Mol. Mass. | 469.984 | ||
SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(Cc2cccc(Cl)c2)s1 |r,wU:7.10,wD:4.3,(44.73,-17.98,;43.19,-18,;42.43,-19.34,;42.4,-16.67,;40.86,-16.69,;40.07,-15.37,;38.53,-15.39,;37.78,-16.74,;38.57,-18.05,;40.1,-18.04,;36.25,-16.75,;35.47,-15.43,;33.93,-15.46,;33.18,-16.79,;33.96,-18.11,;35.5,-18.09,;31.64,-16.81,;30.86,-15.48,;30.88,-18.15,;29.34,-18.16,;28.42,-16.93,;26.96,-17.42,;26.98,-18.96,;25.64,-19.72,;24.31,-18.93,;24.33,-17.39,;23.01,-16.61,;21.67,-17.36,;21.66,-18.91,;20.32,-19.67,;22.98,-19.69,;28.45,-19.42,)| | ||
Structure |