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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50380054 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_810738 (CHEMBL2015971) | ||
| IC50 | 82±n/a nM | ||
| Citation |  Mougenot, P; Namane, C; Fett, E; Camy, F; Dadji-Faïhun, R; Langot, G; Monseau, C; Onofri, B; Pacquet, F; Pascal, C; Crespin, O; Ben-Hassine, M; Ragot, JL; Van-Pham, T; Philippo, C; Chatelain-Egger, F; Péron, P; Le Bail, JC; Guillot, E; Chamiot-Clerc, P; Chabanaud, MA; Pruniaux, MP; Schmidt, F; Venier, O; Nicolaï, E; Viviani, F Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1. Bioorg Med Chem Lett22:2497-502 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Protein | ||
| Mol. Mass.: | 55297.82 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O75907 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50380054 | |||
| n/a | |||
| Name | BDBM50380054 | ||
| Synonyms: | CHEMBL2012632 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H24ClN3O3S | ||
| Mol. Mass. | 469.984 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(Cc2ccccc2Cl)s1 |r,wU:7.10,wD:4.3,(15.75,-24.57,;14.21,-24.58,;13.46,-25.93,;13.43,-23.26,;11.89,-23.28,;11.1,-21.95,;9.56,-21.98,;8.81,-23.32,;9.59,-24.64,;11.13,-24.63,;7.28,-23.34,;6.49,-22.02,;4.95,-22.05,;4.21,-23.38,;4.98,-24.7,;6.53,-24.68,;2.67,-23.39,;1.88,-22.07,;1.91,-24.74,;.37,-24.75,;-.55,-23.52,;-2.01,-24.01,;-1.99,-25.55,;-3.34,-26.31,;-4.66,-25.52,;-4.64,-23.98,;-5.96,-23.2,;-7.31,-23.95,;-7.32,-25.5,;-5.99,-26.28,;-6,-27.82,;-.52,-26.01,)| | ||
| Structure | 
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