Reaction Details |
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Target | RAC-alpha serine/threonine-protein kinase |
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Ligand | BDBM50380932 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_814031 (CHEMBL2020583) |
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IC50 | 42±n/a nM |
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Citation | Rice, KD; Kim, MH; Bussenius, J; Anand, NK; Blazey, CM; Bowles, OJ; Canne-Bannen, L; Chan, DS; Chen, B; Co, EW; Costanzo, S; DeFina, SC; Dubenko, L; Engst, S; Franzini, M; Huang, P; Jammalamadaka, V; Khoury, RG; Klein, RR; Laird, AD; Le, DT; Mac, MB; Matthews, DJ; Markby, D; Miller, N; Nuss, JM; Parks, JJ; Tsang, TH; Tsuhako, AL; Wang, Y; Xu, W Pyrazolopyrimidines as dual Akt/p70S6K inhibitors. Bioorg Med Chem Lett22:2693-7 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAC-alpha serine/threonine-protein kinase |
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Name: | RAC-alpha serine/threonine-protein kinase |
Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) |
Type: | Enzyme |
Mol. Mass.: | 55681.25 |
Organism: | Homo sapiens (Human) |
Description: | P31749 |
Residue: | 480 |
Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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BDBM50380932 |
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n/a |
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Name | BDBM50380932 |
Synonyms: | CHEMBL2016771 |
Type | Small organic molecule |
Emp. Form. | C22H28BrClN8 |
Mol. Mass. | 519.868 |
SMILES | Cc1c(NCCN2CCCC2)cc(Cl)cc1N1CCN(CC1)c1ncnc2n[nH]c(Br)c12 |
Structure |
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