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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | ||
| Ligand | BDBM50381317 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_814419 (CHEMBL2019815) | ||
| IC50 | 14±n/a nM | ||
| Citation |  Banerjee, A; Yadav, PS; Bajpai, M; Sangana, RR; Gullapalli, S; Gudi, GS; Gharat, LA Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation. Bioorg Med Chem Lett22:3223-8 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | |||
| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | ||
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 55514.96 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13946 | ||
| Residue: | 482 | ||
| Sequence: |
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| BDBM50381317 | |||
| n/a | |||
| Name | BDBM50381317 | ||
| Synonyms: | CHEMBL2019134 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H12ClFN4O2S | ||
| Mol. Mass. | 402.83 | ||
| SMILES | COc1cc(N)ccc1-c1nc2snc(-c3c(F)cccc3Cl)c2c(=O)[nH]1 |(-1.75,-41.75,;-.41,-40.98,;.92,-41.75,;2.25,-40.98,;3.59,-41.76,;4.92,-40.99,;3.58,-43.3,;2.25,-44.06,;.92,-43.29,;-.41,-44.05,;-1.74,-43.27,;-3.07,-44.04,;-4.55,-43.56,;-5.46,-44.82,;-4.55,-46.07,;-5.02,-47.53,;-6.53,-47.84,;-7.55,-46.7,;-7,-49.31,;-5.97,-50.45,;-4.46,-50.13,;-3.99,-48.66,;-2.66,-49.43,;-3.07,-45.59,;-1.74,-46.35,;-1.74,-47.89,;-.41,-45.59,)| | ||
| Structure | 
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