| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Ligand | BDBM50381291 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_814420 (CHEMBL2019816) |
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| IC50 | 17±n/a nM |
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| Citation |  Banerjee, A; Yadav, PS; Bajpai, M; Sangana, RR; Gullapalli, S; Gudi, GS; Gharat, LA Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation. Bioorg Med Chem Lett22:3223-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7B | PDE7B_HUMAN | Phosphodiesterase 7B | Phosphodiesterase 7B (PDE7B) | cAMP-specific 3',5'-cyclic phosphodiesterase 7B |
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| Type: | Enzyme |
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| Mol. Mass.: | 51842.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NP56 |
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| Residue: | 450 |
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| Sequence: | MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYS
GEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIF
LFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAAD
VTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMS
VLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHN
KDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEIS
PLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQ
HRSRGSSGSGPDHDHAGQGTESEEQEGDSP
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| BDBM50381291 |
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| n/a |
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| Name | BDBM50381291 |
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| Synonyms: | CHEMBL2019104 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29N5O2S |
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| Mol. Mass. | 439.574 |
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| SMILES | COc1cc(ccc1-c1nc2snc(C3CCCCC3)c2c(=O)[nH]1)N1CCCNCC1 |
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| Structure | 
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