Reaction Details | |||
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Target | Mitogen-activated protein kinase 14 | ||
Ligand | BDBM50382379 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_817608 (CHEMBL2027256) | ||
IC50 | 53±n/a nM | ||
Citation | Duffy, JP; Harrington, EM; Salituro, FG; Cochran, JE; Green, J; Gao, H; Bemis, GW; Evindar, G; Galullo, VP; Ford, PJ; Germann, UA; Wilson, KP; Bellon, SF; Chen, G; Taslimi, P; Jones, P; Huang, C; Pazhanisamy, S; Wang, YM; Murcko, MA; Su, MS The Discovery of VX-745: A Novel and Selective p38a Kinase Inhibitor. ACS Med Chem Lett2:758-763 (2011) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase 14 | |||
Name: | Mitogen-activated protein kinase 14 | ||
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 41286.76 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q16539 | ||
Residue: | 360 | ||
Sequence: |
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BDBM50382379 | |||
n/a | |||
Name | BDBM50382379 | ||
Synonyms: | CHEMBL420134 | ||
Type | Small organic molecule | ||
Emp. Form. | C19H9Cl3FN3OS | ||
Mol. Mass. | 452.717 | ||
SMILES | Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(Cl)c1 |(16.76,-12.29,;15.44,-11.5,;14.1,-12.27,;12.77,-11.5,;12.78,-9.96,;11.45,-9.18,;10.12,-9.95,;10.11,-11.49,;8.77,-12.23,;7.45,-11.46,;6.11,-12.23,;6.11,-13.77,;7.45,-14.54,;8.77,-13.77,;7.45,-16.08,;6.11,-16.85,;4.78,-16.08,;4.78,-14.54,;3.44,-13.77,;4.79,-11.46,;3.46,-12.23,;4.79,-9.92,;6.11,-9.15,;7.45,-9.92,;8.79,-9.15,;14.12,-9.19,;14.12,-7.65,;15.44,-9.96,)| | ||
Structure |