Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
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Ligand | BDBM50382819 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_815023 (CHEMBL2027169) |
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EC50 | >100000±n/a nM |
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Citation | Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice. Bioorg Med Chem Lett22:2748-52 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase type 2 |
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Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase type 2 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_MOUSE | Hsd11b2 | Hsd11k | NAD-dependent 11-beta-hydroxysteroid dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 42201.46 |
Organism: | Mus musculus (mouse) |
Description: | Purified recombinant mouse 11beta-HSD2. |
Residue: | 386 |
Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVV
LAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPG
ALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELS
PVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIA
LLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYI
EHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRR
CFLQNFFINHLLPRALRPGQHGPAPA
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BDBM50382819 |
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n/a |
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Name | BDBM50382819 |
Synonyms: | CHEMBL2023584 |
Type | Small organic molecule |
Emp. Form. | C23H31ClN4O4S |
Mol. Mass. | 495.035 |
SMILES | Clc1ccc2NC(=O)N(CC3CCN(CC3)C(=O)N(C3CC3)C3CCCCC3)S(=O)(=O)c2c1 |
Structure |
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