| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Ligand | BDBM50382820 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_815023 (CHEMBL2027169) |
|---|
| EC50 | >100000±n/a nM |
|---|
| Citation |  Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice. Bioorg Med Chem Lett22:2748-52 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 11-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Name: | 11-beta-hydroxysteroid dehydrogenase type 2 |
|---|
| Synonyms: | 11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase type 2 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_MOUSE | Hsd11b2 | Hsd11k | NAD-dependent 11-beta-hydroxysteroid dehydrogenase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42201.46 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | Purified recombinant mouse 11beta-HSD2. |
|---|
| Residue: | 386 |
|---|
| Sequence: | MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVV
LAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNSPG
ALELRDLCSPRLKLLQMDLTKAEDISRVLEITKAHTASTGLWGLVNNAGLNIVVADVELS
PVATFRKCMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIA
LLMDTFGCELLPWGIKVSIIKPGCFKTDAVTNVNLWEKRKQLLLANIPRELLQAYGEDYI
EHVHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYPGRGLGLMYFIHHYLPEGLRR
CFLQNFFINHLLPRALRPGQHGPAPA
|
|
|
|---|
| BDBM50382820 |
|---|
| n/a |
|---|
| Name | BDBM50382820 |
|---|
| Synonyms: | CHEMBL2023585 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H31ClN4O4S |
|---|
| Mol. Mass. | 483.024 |
|---|
| SMILES | CN(C1CCCCCC1)C(=O)N1CCC(CN2C(=O)Nc3ccc(Cl)cc3S2(=O)=O)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
