Reaction Details |
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Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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Ligand | BDBM50382829 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_815021 (CHEMBL2027167) |
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EC50 | 14±n/a nM |
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Citation | Zhang, L; Chen, J; Ning, M; Zou, Q; Leng, Y; Shen, J Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice. Bioorg Med Chem Lett22:2748-52 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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11-beta-hydroxysteroid dehydrogenase 1 |
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Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 |
Type: | Enzyme |
Mol. Mass.: | 32369.70 |
Organism: | Mus musculus (mouse) |
Description: | P50172 |
Residue: | 292 |
Sequence: | MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
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BDBM50382829 |
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n/a |
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Name | BDBM50382829 |
Synonyms: | CHEMBL2023425 |
Type | Small organic molecule |
Emp. Form. | C25H26ClN3O4S |
Mol. Mass. | 500.01 |
SMILES | Clc1ccc2NC(=O)N(Cc3ccc(cc3)C(=O)NC34CC5CC(CC(C5)C3)C4)S(=O)(=O)c2c1 |TLB:22:23:20.21.26:27,THB:22:21:27:28.23.24,24:23:20:26.25.27,24:25:20:28.22.23| |
Structure |
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