Reaction Details |
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Target | Receptor-type tyrosine-protein kinase FLT3 |
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Ligand | BDBM50384727 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_820932 (CHEMBL2038873) |
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IC50 | 5100±n/a nM |
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Citation | Albaugh, P; Fan, Y; Mi, Y; Sun, F; Adrian, F; Li, N; Jia, Y; Sarkisova, Y; Kreusch, A; Hood, T; Lu, M; Liu, G; Huang, S; Liu, Z; Loren, J; Tuntland, T; Karanewsky, DS; Seidel, HM; Molteni, V Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett3:140-145 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Receptor-type tyrosine-protein kinase FLT3 |
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Name: | Receptor-type tyrosine-protein kinase FLT3 |
Synonyms: | CD_antigen=CD135 | FL cytokine receptor | FLT3_MOUSE | Fetal liver kinase 2 | Flk-2 | Flt-3 | Flt3 | Fms-like tyrosine kinase 3 | Tyrosine-protein kinase receptor flk-2 |
Type: | PROTEIN |
Mol. Mass.: | 113492.59 |
Organism: | Mus musculus |
Description: | ChEMBL_104536 |
Residue: | 1000 |
Sequence: | MRALAQRSDRRLLLLVVLSVMILETVTNQDLPVIKCVLISHENNGSSAGKPSSYRMVRGS
PEDLQCTPRRQSEGTVYEAATVEVAESGSITLQVQLATPGDLSCLWVFKHSSLGCQPHFD
LQNRGIVSMAILNVTETQAGEYLLHIQSEAANYTVLFTVNVRDTQLYVLRRPYFRKMENQ
DALLCISEGVPEPTVEWVLCSSHRESCKEEGPAVVRKEEKVLHELFGTDIRCCARNALGR
ESTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYFE
MSTYSTNRTMIRILLAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEKGFINATSSQEEY
EIDPYEKFCFSVRFKAYPRIRCTWIFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFY
AENDDAQFTKMFTLNIRKKPQVLANASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIP
EGVWNKKANRKVFGQWVSSSTLNMSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPFPFIQ
DNISFYATIGLCLPFIVVLIVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYVDFRDYEY
DLKWEFPRENLEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALM
SELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFK
EHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNSIHSEDEIEYENQKRLAEEEE
EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIL
SDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDAN
FYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEEAMYQN
MGGNVPEHPSIYQNRRPLSREAGSEPPSPQAQVKIHRERS
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BDBM50384727 |
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n/a |
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Name | BDBM50384727 |
Synonyms: | CHEMBL2037226 |
Type | Small organic molecule |
Emp. Form. | C28H21F4N5O2 |
Mol. Mass. | 535.4923 |
SMILES | Cc1ccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)cc1Nc1ccc2\C(=C\c3ccc[nH]3)C(=O)Nc2c1 |
Structure |
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