| Reaction Details |
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 | Report a problem with these data |
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Ligand | BDBM77437 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_823668 (CHEMBL2044827) |
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| IC50 | 860±n/a nM |
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| Citation |  Redondo, M; Brea, J; Perez, DI; Soteras, I; Val, C; Perez, C; Morales-García, JA; Alonso-Gil, S; Paul-Fernandez, N; Martin-Alvarez, R; Cadavid, MI; Loza, MI; Perez-Castillo, A; Mengod, G; Campillo, NE; Martinez, A; Gil, C Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds. J Med Chem55:3274-84 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55514.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13946 |
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| Residue: | 482 |
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| Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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| BDBM77437 |
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| n/a |
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| Name | BDBM77437 |
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| Synonyms: | 1-({[5-(ethoxycarbonyl)-4-methyl-1,3-thiazol-2-yl]amino}carbonyl)propyl N-benzoylleucinate | 2-[2-(2-benzamido-4-methyl-pentanoyl)oxybutanoylamino]-4-methyl-thiazole-5-carboxylic acid ethyl ester | 2-[[2-(2-benzamido-4-methyl-1-oxopentoxy)-1-oxobutyl]amino]-4-methyl-5-thiazolecarboxylic acid ethyl ester | MLS000575128 | SMR000196362 | cid_2915100 | ethyl 2-[2-(2-benzamido-4-methyl-pentanoyl)oxybutanoylamino]-4-methyl-1,3-thiazole-5-carboxylate | ethyl 2-[2-(2-benzamido-4-methylpentanoyl)oxybutanoylamino]-4-methyl-1,3-thiazole-5-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C24H31N3O6S |
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| Mol. Mass. | 489.584 |
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| SMILES | CCOC(=O)c1sc(NC(=O)C(CC)OC(=O)C(CC(C)C)NC(=O)c2ccccc2)nc1C |
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| Structure | 
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