| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50386179 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_823808 (CHEMBL2045410) |
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| IC50 | 45900±n/a nM |
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| Citation |  Carvalho, SA; Feitosa, LO; Soares, M; Costa, TE; Henriques, MG; Salomão, K; de Castro, SL; Kaiser, M; Brun, R; Wardell, JL; Wardell, SM; Trossini, GH; Andricopulo, AD; da Silva, EF; Fraga, CA Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents. Eur J Med Chem54:512-21 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50386179 |
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| n/a |
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| Name | BDBM50386179 |
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| Synonyms: | CHEMBL2042791 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3O8 |
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| Mol. Mass. | 431.396 |
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| SMILES | COc1cc(\C=N\NC(=O)\C=C\c2cc(OC)c(OC)c(OC)c2)cc(c1O)[N+]([O-])=O |
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| Structure | 
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