| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 1 |
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| Ligand | BDBM50386889 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_827407 (CHEMBL2051077) |
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| IC50 | >100000±n/a nM |
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| Citation |  Ohtake, Y; Sato, T; Matsuoka, H; Kobayashi, T; Nishimoto, M; Taka, N; Takano, K; Yamamoto, K; Ohmori, M; Higuchi, T; Murakata, M; Morikawa, K; Shimma, N; Suzuki, M; Hagita, H; Ozawa, K; Yamaguchi, K; Kato, M; Ikeda, S C-Aryl 5a-carba-ß-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem20:4117-27 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/glucose cotransporter 1 |
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| Name: | Sodium/glucose cotransporter 1 |
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| Synonyms: | High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1 |
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| Type: | Protein |
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| Mol. Mass.: | 73503.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P13866 |
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| Residue: | 664 |
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| Sequence: | MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
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| BDBM50386889 |
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| n/a |
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| Name | BDBM50386889 |
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| Synonyms: | CHEMBL2048493 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H32O6 |
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| Mol. Mass. | 416.5073 |
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| SMILES | CCOc1ccc(Cc2ccc(CC)cc2)cc1[C@]1(O)C[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r| |
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| Structure | 
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