| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 12 member 2 |
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| Ligand | BDBM43891 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_828044 (CHEMBL2049738) |
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| IC50 | >50000±n/a nM |
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| Citation |  Delpire, E; Baranczak, A; Waterson, AG; Kim, K; Kett, N; Morrison, RD; Daniels, JS; Weaver, CD; Lindsley, CW Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett22:4532-5 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 12 member 2 |
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| Name: | Solute carrier family 12 member 2 |
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| Synonyms: | Basolateral Na-K-Cl symporter | Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1 | NKCC1 | S12A2_HUMAN | SLC12A2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 131443.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_828044 |
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| Residue: | 1212 |
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| Sequence: | MEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEG
PAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADG
EASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLS
EGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLR
PSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIW
GVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSL
GPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVIL
LGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPD
FREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSV
GSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFT
PLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFL
IALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGA
ILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGV
EDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQA
KYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDV
DMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKS
DLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQG
KNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFR
IDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELE
LYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLV
RGNHQSVLTFYS
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| BDBM43891 |
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| n/a |
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| Name | BDBM43891 |
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| Synonyms: | N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanyl-ethanamide | N-(4-methyl-1,3-thiazol-2-yl)-2-(6-phenylpyridazin-3-yl)sulfanylacetamide | N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide | N-(4-methylthiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)thio]acetamide | VU0240551-2-D4 | cid_7211972 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14N4OS2 |
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| Mol. Mass. | 342.439 |
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| SMILES | Cc1csc(NC(=O)CSc2ccc(nn2)-c2ccccc2)n1 |
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| Structure | 
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