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TargetCytochrome P450 2D6 (2D6)
LigandBDBM50388532
Substrate/Competitorn/a
Meas. Tech.ChEMBL_830279
IC50>6000±n/a nM
Citation Nagle AWu TKuhen KGagaring KBorboa RFrancek CChen ZPlouffe DLin XCaldwell CEk JSkolnik SLiu FWang JChang JLi CLiu BHollenbeck TTuntland TIsbell JChuan TAlper PBFischli CBrun RLakshminarayana SBRottmann MDiagana TTWinzeler EAGlynne RTully DCChatterjee AK Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. J Med Chem 55:4244-73 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6 (2D6)
Name:Cytochrome P450 2D6
Synonyms:CYPIID6 | Cytochrome P450 2D6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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  Blast E-value cutoff:
BDBM50388532
n/a
NameBDBM50388532
Synonyms:CHEMBL2058833
TypeSmall organic molecule
Emp. Form.C22H23F2N5O
Mol. Mass.411.4477
SMILESCC1(C)N(CCn2c(Nc3ccc(F)cc3)c(nc12)-c1ccc(F)cc1)C(=O)CN
Structure
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