| Reaction Details |
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 | Report a problem with these data |
| Target | Homeodomain-interacting protein kinase 2 |
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| Ligand | BDBM50388781 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_830911 (CHEMBL2065460) |
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| IC50 | 570±n/a nM |
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| Citation |  Dowling, JE; Chuaqui, C; Pontz, TW; Lyne, PD; Larsen, NA; Block, MH; Chen, H; Su, N; Wu, A; Russell, D; Pollard, H; Lee, JW; Peng, B; Thakur, K; Ye, Q; Zhang, T; Brassil, P; Racicot, V; Bao, L; Denz, CR; Cooke, E Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization. ACS Med Chem Lett3:278-283 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Homeodomain-interacting protein kinase 2 |
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| Name: | Homeodomain-interacting protein kinase 2 |
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| Synonyms: | HIPK2 | HIPK2_HUMAN | Homeodomain-interacting protein kinase 2 | Homeodomain-interacting protein kinase 2 (HIPK2) |
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| Type: | Protein |
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| Mol. Mass.: | 131001.90 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H2X6 |
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| Residue: | 1198 |
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| Sequence: | MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLS
QPATTTVSTSLPVPNPSLPYEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHNLMRRSTV
SLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG
QIEVSILARLSTESADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY
IRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLP
AEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN
MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTS
ATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPP
GFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAA
QPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPP
RCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQ
KHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHC
TGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGA
ITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSH
GTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASI
VHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASPASTVYTGYPLSPAKVNQYPYI
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| BDBM50388781 |
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| n/a |
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| Name | BDBM50388781 |
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| Synonyms: | CHEMBL2062585 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N7O3 |
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| Mol. Mass. | 443.4579 |
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| SMILES | CC(=O)Nc1ccc2n(CCC(O)=O)cc(-c3cc(NC4CC4)n4ncc(C#N)c4n3)c2c1 |
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| Structure | 
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