| Reaction Details |
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 | Report a problem with these data |
| Target | Dynamin-1 |
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| Ligand | BDBM50388829 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_831002 (CHEMBL2065654) |
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| IC50 | 5900±n/a nM |
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| Citation |  Robertson, MJ; Hadzic, G; Ambrus, J; Pomè, DY; Hyde, E; Whiting, A; Mariana, A; von Kleist, L; Chau, N; Haucke, V; Robinson, PJ; McCluskey, A The Rhodadyns, a New Class of Small Molecule Inhibitors of Dynamin GTPase Activity. ACS Med Chem Lett3:352-356 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dynamin-1 |
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| Name: | Dynamin-1 |
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| Synonyms: | DNM | DNM1 | DYN1_HUMAN | Dynamin-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97411.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1458576 |
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| Residue: | 864 |
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| Sequence: | MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPI
NLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSD
LANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKL
QSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGA
RINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKI
REPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLID
IELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKE
YWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY
RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVE
TIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAE
QAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT
PQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAP
PGVPSRSGQASPSRPESPRPPFDL
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| BDBM50388829 |
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| n/a |
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| Name | BDBM50388829 |
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| Synonyms: | CHEMBL2062753 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22N2O2S2 |
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| Mol. Mass. | 362.509 |
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| SMILES | CN(C)CCCOc1ccc(\C=C2/SC(=S)N(CC=C)C2=O)cc1 |
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| Structure | 
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