| Reaction Details |
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 | Report a problem with these data |
| Target | Neutral cholesterol ester hydrolase 1 |
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| Ligand | BDBM50390510 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_835313 (CHEMBL2072019) |
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| IC50 | 710±n/a nM |
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| Citation |  Shreder, KR; Lin, EC; Wu, J; Cajica, J; Amantea, CM; Hu, Y; Okerberg, E; Brown, HE; Pham, LM; Chung, de M; Fraser, AS; McGee, E; Rosenblum, JS; Kozarich, JW Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1). Bioorg Med Chem Lett22:5748-51 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutral cholesterol ester hydrolase 1 |
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| Name: | Neutral cholesterol ester hydrolase 1 |
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| Synonyms: | AADACL1 | KIAA1363 | NCEH1 | NCEH1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45810.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_835312 |
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| Residue: | 408 |
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| Sequence: | MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVSNLIHYLGLSHHLL
ALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALA
SAKIRYYDELCTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMV
DPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNT
PILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNY
KPVVQTTGNARIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKR
LESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
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| BDBM50390510 |
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| n/a |
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| Name | BDBM50390510 |
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| Synonyms: | CHEMBL2071659 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14BrNO2 |
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| Mol. Mass. | 356.213 |
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| SMILES | Brc1c(OC(=O)NCc2ccccc2)ccc2ccccc12 |
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| Structure | 
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