Reaction Details |
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Target | Inward rectifier potassium channel 2 |
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Ligand | BDBM50391770 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_849883 (CHEMBL2148627) |
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IC50 | >100000±n/a nM |
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Citation | Tang, H; Walsh, SP; Yan, Y; de Jesus, RK; Shahripour, A; Teumelsan, N; Zhu, Y; Ha, S; Owens, KA; Thomas-Fowlkes, BS; Felix, JP; Liu, J; Kohler, M; Priest, BT; Bailey, T; Brochu, R; Alonso-Galicia, M; Kaczorowski, GJ; Roy, S; Yang, L; Mills, SG; Garcia, ML; Pasternak, A Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics. ACS Med Chem Lett3:367-372 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inward rectifier potassium channel 2 |
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Name: | Inward rectifier potassium channel 2 |
Synonyms: | Cardiac inward rectifier potassium channel | IRK-1 | IRK1 | Inward rectifier K(+) channel Kir2.1 | KCNJ2 | KCNJ2_HUMAN | Potassium channel, inwardly rectifying subfamily J member 2 | hIRK1 |
Type: | PROTEIN |
Mol. Mass.: | 48281.20 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1515520 |
Residue: | 427 |
Sequence: | MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFIN
VGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGK
ACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVM
AKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEG
EYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEG
MVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARD
LAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRP
LRRESEI
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BDBM50391770 |
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n/a |
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Name | BDBM50391770 |
Synonyms: | CHEMBL2146755 | US9073882, 1 |
Type | Small organic molecule |
Emp. Form. | C20H24N4O4 |
Mol. Mass. | 384.429 |
SMILES | [O-][N+](=O)c1ccc(CCN2CCN(CCc3ccc(cc3)[N+]([O-])=O)CC2)cc1 |
Structure |
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